Zoladex - a drug for the treatment of diseases of the reproductive system in urology, gynecology.
Zoladex is an analogue of gonadotropin hormone synthetic origin. Its action is based on the fact that the active ingredient of the drug inhibits the production of luteinizing hormone by the pituitary, which in turn leads to lower levels of estradiol in women, testosterone in men.
Effect of the drug is reversible and hormones in patients recovered after treatment.
There are reviews of Zoladex, which is due to the action, due to a decrease in testosterone levels prostate tumor growth in men stopped and symptomatic improvement occurred. Reduced hormone levels to castration levels observed on day 21 of treatment.
In women, the hormone level is reduced to the level of estradiol menopause, also for 21 days of therapy. Such an effect of the drug is effective in endometriosis, uterine fibroids, hormone-breast cancer, the need for suppressing the development of ovarian follicles.
In combination with the drug in women with iron leads to amenorrhea (absence of menstruation), haematological parameters and increases hemoglobin in the uterine fibroids, and emerged on the background of her anemia. Only in rare cases menstruation can not be restored after discontinuation of the drug.
The active ingredient of the drug - goserelin acetate.
Capsules for administration subcutaneously.
The analogue Zoladex - Goserelin formulation.
Zoladex prescribed for endometriosis, uterine fibroids, breast cancer, in preparation for operations on the endometrium for its thinning.
There are reviews of Zoladex, that it is successfully used in vitro fertilization.
Zoladex Guide: how to use
Adult drug is administered in a dosage of 3, 6 mg subcutaneously every 28 days in the front abdominal wall.
In malignant tumors show prolonged use of Zoladex, benign - not more than six months.
In preparation for operations on the endometrium do two injections a month apart. Surgery is recommended to appoint the first two weeks after the second dose.
According to the instructions Zoladex in vitro fertilization, it is administered in a dosage of 3, 6 mg to reduce the sensitivity of the pituitary gland.
Patients with hepatic, renal insufficiency, in old age the dosage is not adjusted.
The scheme of the analog Zoladex may vary, must make the doctor appointment.
Use of Zoladex may be accompanied by hypotension, hypertension, non-specific sensory symptoms, arthralgia, allergic reactions, skin rash.
In men, Zoladex can cause sweating, pain and swelling of the breasts, the deterioration of potency tides. Patients with prostate cancer may feel at the beginning of therapy, bone pain, sometimes - compression of the spinal cord, the violation of ureteral patency.
There are reviews of Zoladex, causing a change in women libido and mood, headaches, sweating, depression, vaginal dryness of mucous, change in breast size. Women with breast cancer may notice a temporary increase of symptoms.
Zoladex combination with gonadotropins may cause ovarian hyperstimulation, therefore it is necessary for stimulation therapy control cycle.
Zoladex and most unique Zoladex should not be taken by pregnant women, nursing women, children, in case of hypersensitivity.
The instructions Zoladex no data on the negative effects of the drug on human psychomotor reaction, Bad it is combined with other drugs.