Zofran is an antiemetic drug.
Zofran ability to block the emergence of the gag reflex is due to its antagonistic action of the active ingredient - ondansetron. The properties of this material allow to inhibit serotonin receptors of the peripheral and central nervous system, causing a gag reflex.
After oral administration Zofran is well absorbed in the digestive tract. The maximum concentration of ondansetron is 1 to 5 hours after oral administration and 6 hours after application of Zofran rectal suppositories. Withdrawal of the drug by the kidneys. The half-life, usually corresponds to 3-6 hours, in renal impairment - 15-32 hours.
Assign manual recommends Zofran for nausea and vomiting, which were caused by increased levels of serotonin - in cytostatic radiotherapy and chemotherapy or after surgery.
Instructions for use Zofran
Zofran is produced in the form of a solution intended for intramuscular and intravenous administration, syrup, tablets, coated tablets, lozenges, rectal suppository.
Zofran tablets, coated tablets should be swallowed as a whole without crushing with water. Zofran lozenges should be kept in the mouth until dissolved. Zofran Syrup guide recommends not to breed. The duration of treatment data form, the preparation is determined by the attending physician.
When radiation and chemotherapy recommended single dose of Zofran - 8 mg. Appointed 1-2 hours prior to initiation of therapy and again after 12 hours. In order to prevent late emesis Zofran assigned two times a day for 5 days after last treatment. Children under the same scheme administered 4 mg ondansetron, replacing the reception Zofran before chemotherapy, intramuscular or intravenous administration of the drug.
Zofran tablet or syrup can be taken adult patients before surgery - 1 hour before general anesthesia in one dose of 16 mg.
Zofran candles intended for insertion into the anal canal. This form of the drug is usually given to adults during the course of radio- or chemotherapy - 1-2 hours before treatment to 1 suppository. Prevention of late vomiting involves the use of Zofran 1 candle daily for 5 days after completion of therapy.
For intravenous and intramuscular administered Zofran 8 mg to 32 mg per day, depending on the type of treatment and the desired effect.
According to the instructions, Zofran can cause undesirable effects such as:
- dryness of the oral mucosa, the violation of a chair, vomiting, nausea, hiccups, increased liver enzymes;
- cramps, dizziness, headache;
- bradycardia (reduced heart rate), low blood pressure, heart pain, flushing (overflow blood vessels) of the upper part of the body or face;
- increased level of creatinine in the blood, impaired vision;
- Allergic reactions on the skin;
- the application of Zofran candles - burning in the anus; when administered intravenously - inflammation, irritation, pain at the injection site.
Contraindications to the use of Zofran
Zofran is not administered to children under 2 years old, pregnant and lactating patients, as well as in case of hypersensitivity to the drug.
Zofran candles is not recommended for children under 18 years.
Caution should be used when Zofran sub-acute intestinal obstruction, cardiac arrhythmias and conduction, violation of water-electrolyte balance.
Be wary appointed Zofran elderly patients.
Store Zofran be at a temperature corresponding to 15-30
C, away from the sunlight.
Shelf life lozenge - 2 years, other forms of the drug - 3 years. Ready infusion solution should be stored in a cool place (2-8
C) is not longer than 24 hours.