Zantac

Zantac - antiulcer agent.  Zantac drug tablets.

Release form and composition of the drug Zantac

  • Zantac injection, ampoules of 2 mL, 5 vials per pack. 1 ml contains the active substance - 25 mg of ranitidine hydrochloride. Supporting components: water for injection, anhydrous dibasic sodium dibasic, sodium chloride, monopotassium phosphate.
  • Zantac tablet 150 mg or 300 mg coated tablets in blister packs of 10 or 15 tablets, in packs of two or four blister. 1 tablet contains ranitidine hydrochloride 150 mg or 300 mg. Auxiliary components: triacetin, titanium dioxide, magnesium stearate, MCC, methylhydroxypropylcellulose, sodium croscarmellose.
  • Zantac soluble tablets for the preparation of fizzy drink, 150 mg or 300 mg. 1 soluble tablet contains ranitidine hydrochloride 150 mg or 300 mg, in tubes of 10 or 15 units, in packages of one or two tubes. Auxiliary components: grapefruit and orange flavors, sodium benzoate, povidone K30, sodium, aspartame, anhydrous monosodium citrate.

Pharmacological action

Ranitidine blocks histamine H2-receptors of parietal cells of the intestinal mucosa, providing anti-ulcer effect.

Pokazaniyak use of the drug Zantac

According to the instructions Zantac is prescribed for treatment and prevention of ulcers, 12 duodenal ulcer and stomach, as well as:

  • For the treatment of ulcer and duodenum 12 and the stomach caused by NSAID;
  • With Zollinger-Ellison syndrome;
  • As a preventive measure against recurrence of bleeding from the upper gastrointestinal tract;
  • In the prophylactic and therapeutic purposes in postoperative and "stress" ulcers of the stomach;
  • To prevent aspiration of gastric juice in the operations under general anesthesia (Mendelson's syndrome);
  • When erosive esophagitis, reflux esophagitis.

Contraindications Zantac

Zantac is contraindicated for instructions:

  • With increased intolerance ranitidine or other component of the formulation;
  • During pregnancy and during lactation;
  • In children under 12 years.

The instructions to the Zantac indicated that it should be used with caution in patients with renal or hepatic insufficiency, acute porphyria, liver cirrhosis with portosystemic encephalopathy in history.

Side effects of Zantac

Use according to the instructions Zantac solution for injection can cause such side effects:

  • Hematopoietic system: reversible thrombocytopenia and leukopenia. In rare cases, you may pancytopenia or agranulocytosis.
  • Bodies of: blurred vision occurs predominantly related to changes in accommodation.
  • Musculoskeletal system: it is possible to observe rare phenomenon myalgia and arthralgia.
  • Cardiovascular system: tachycardia, AV block, bradycardia. There are rare cases of vasculitis.
  • Pancreas, bile duct and liver: acute pancreatitis, hepatitis (mixed, cholestatic or hepatocellular), and transient changes in liver function tests.
  • Kidneys are rarely observed occurrence of acute interstitial nephritis;
  • Reproductive system: the case of rare symptoms in men from the breast, there is a reversible impotence.
  • Allergic reactions: alopecia, erythema multiforme and hypersensitivity reactions (fever, rash, bronchospasm, chest pain, hypotension, angioedema, anaphylactic shock).

Use according to the instructions Zantac tablets may cause the following side effects:

  • The system hematopoiesis: agranulocytosis, leukopenia, pancytopenia, immune hemolytic anemia, hypo- and aplasia of the bone marrow.
  • Digestive system: diarrhea, constipation, vomiting, nausea, dry mouth, acute pancreatitis, abdominal pain.
  • Senses: paresis of accommodation, reduction in visual acuity.
  • Cardiovascular system: lowering blood pressure.
  • The central nervous system irritability, tinnitus, involuntary movements.
  • Musculoskeletal: myalgia, arthralgia.

Method of use and dosage of Zantac

Zantac by instructions administered orally, intravenously, intramuscularly.

 The drug Zantac Injection.
 Parenterally. Adults make slow intravenous injection (over two minutes) every 6-8 hours at a dose of 50 mg, diluted to a volume of 20 ml or intermittent intravenous infusion at a rate of 25 mg per hour for two hours with repeated administration at 6-8 hours or intramuscular injection at a dosage of 50 mg every 6-8 hours.

Tablets Zantac taking 150 mg twice daily or 300 mg once, in the evening before bedtime.

Cautions

The use of ranitidine may mask the symptoms caused by gastric carcinoma. Therefore, patients with gastric ulcer before applying Zantac should eliminate the possibility of malignancy.





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