Zaditen

Zaditen - pharmacological agents from the group of anti-allergic agents. The active ingredient - ketotifen.  The drug Zaditen tablets.

Structure and Composition

According to the instructions Zaditen is available as tablets, syrup for children and eye drops.

Zaditen 1 tablet containing 1 mg ketotifen (in the form gidrogenfumarata) and auxiliaries. In one package of 30 tablets of the drug.

Zaditen syrup for children 5 ml contains 1 mg ketotifen (in the form gidrogenfumarata). Syrup is produced in bottles of 100 ml.

Eyedrops Zaditen contain 0, 25 mg in 1 ml of ketotifen. Produced eye drops in bottles of 5 ml.

Pharmacological action Zaditen

The drug has anti-allergic (antihistamine) action. According to the instructions Zaditen blocking the release of biologically active substances involved in inflammation reaction (histamine, leukotrienes, prostaglandins and platelet activating factor) from mast cells and stabilizes membranes of these cells. Also, the drug inhibits the accumulation of eosinophils in the blood. According to the instructions Zaditen blocks H1 histamine receptors and prevents the development of allergic reactions of the immediate type.

When receiving Zaditen inward 50% of its metabolized in the liver. The maximum drug concentration in the blood was within 2-4 hours after ingestion. 75% of the drug binds to serum proteins. Zaditen is displayed from the body all the way through 21 hours, mainly kidneys.

Indications

  • asthma (prevention of attacks, as well as in the period of exacerbation);
  • allergic diseases (prevention and treatment);
  • acute and chronic urticaria;
  • atopic dermatitis;
  • allergic rhinitis;
  • allergic conjunctivitis.

Contraindications to the use Zaditen

Hypersensitivity to the components of the drug. To apply caution in children under 3 years (if the potential benefits of using the drug higher risk).

Use during pregnancy and lactation

Clinical studies on safety Zaditen in these patients was conducted. Therefore, the use of this drug during pregnancy and breastfeeding is not recommended.

Dosing and Administration Zaditen

Zaditen tablets should be taken orally. Adults appoint 1-2 mg 2 times a day. The maximum daily dose of 4 mg / day.

 Preparation Zaditen syrup.
 Children dosage of the drug is prescribed according to age.

Children aged 6 months to 3 years is recommended to take at 0, 05 mg / kg Zaditen twice a day (in the form of a syrup 0, 25 ml / kg). Children older than 3 years Zaditen under the instruction assigned to 1 mg twice daily (5 ml syrup).

Eyedrops Zaditen administered 1 drop (in the conjunctival sac of each), 2 times a day. Patients over 65 dose adjustment is required.

The duration of therapy with this drug should not exceed six weeks.

side effect

When you receive this medication, you may experience the following side effects: headache, drowsiness, skin rash, eczema, urticaria, dry mouth. In the opinion of Zaditen the frequency of side effects is less than 1%.

On the part of the organ of vision when applying drops Zaditen may cause burning eyes, corneal erosion point (in 1-2% of cases). Also recorded a syndrome of "dry eye", conjunctivitis, photophobia, subconjunctival hemorrhage, swelling and itching of the eyelids. According to the instructions Zaditen such side effects occur in less than 1% of cases.

Overdose Zaditenom

These cases of overdose with this drug are not available. If you accidentally receiving Zaditen eye drops into the side-effects were observed. It is known that intake of ketotifen in a dose of 20 mg per day do not cause serious symptoms.

Interaction with other drugs

No data on the interaction Zaditen with other pharmacological agents.

Cautions when using Zaditen

Note that the eye drops Zaditen contain benzalkonium chloride, which can penetrate soft contact lens. Therefore, use of these droplets may only after removal of contact lenses. Dress lenses should be no earlier than 15 minutes after instillation of the drug. If there is a need multiple drugs instillation into conjunctival cavity, you should make a break between them for at least 5 minutes.

Effect on ability to drive vehicles and operate machinery

In case of drowsiness on the background of the use of Zaditen (or blurred vision while using drops) should abandon the DMV or using machinery.





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