Vivitrol - a drug designed to correct disorders in substance abuse, drug addiction and alcoholism. Preparations Antakson, naltrexone, naltrexone hydrochloride, Narkanti, Narcan, Revia - Vivitrol counterparts. The uniqueness of this product is that under its influence torn associations between substance use and enjoyment.
Structure and Composition
The instructions to Vivitrol said that the drug is available as a powder for suspension. Restored suspension is white or white with a slightly yellowish color. The powder is placed in glass vials of 5 ml complete with a syringe (5 ml) three needles and solvent. One vial contains 430 mg of Vivitrol naltrexone - the main active ingredient of the drug. The solvent is a clear, colorless liquid. The composition of the solvent include carmellose sodium, polysorbate, water for injection and sodium chloride.
Pharmacological action Vivitrol
The spinal cord and brain, the gastrointestinal tract and other organs of the human body located great number of receptors
. Among them are the so-called opioid receptors (nociceptive, δ- delta, μ- mu and kappa κ-)
. Opioid receptors regulate pain
. In intramuscular Vivitrol accumulates in muscle tissue
. During the month, he is from the muscle tissue is slowly absorbed into the blood
. Next, it is gradually reacted with opioid receptors and blocks their
. In a review of Vivitrol it said that the use of this drug is not usually accompanied by the development of physiological and psychological dependence or tolerance
. The mechanism of action of the drug not completely understood, however, suggest that it affects the endogenous opioid system
. Vivitrol is not a means to aversive therapy
. It does not cause disulfiramopodobnyh reaction when taking alcohol or opiates
The drug is used to remove the alcohol addiction. The drug may be used, patients are able to abstain from drinking alcohol active before starting therapy. Treatment Vivitrol can be part of a comprehensive program of psychosocial support in addressing alcohol dependence.
Prior to use Vivitrol patients should stop taking opioid substances for one to two weeks in order to prevent the development of acute cancel or prevent aggravation of already existing symptoms.
Vivitrol - Instructions for use
According to the instructions Vivitrol be administered intramuscularly in the dose 380 mg once every four weeks. The drug is recommended to be administered in the buttock muscles. The drug should not be administered intravenously. When skipping the next injection dose the next administration should be done as quickly as possible.
Before use, the package with Vivitrol comes from the refrigerator and allowed to warm to room temperature. Then, put a needle for suspension on the syringe and withdrawn 3, 4 mL of solvent. Then the solvent is introduced into the vial with Vivitrol. Agitation powder and solvent vial shaken vigorously for about one minute. Right stirred suspension is a milky-white color. Immediately after the preparation is taken up in a syringe 4, 2 ml of the suspension. Take off the needle and put the needle on the syringe for injection. Before the introduction of the sample is carried out on the aspiration of blood. Gradually introduce Vivitrol smooth movement deep into the muscle. After the introduction of the drug close the needle protective cap.
Vivitrol and analogues Vivitrol contraindicated when taking narcotic analgesics, opioid dependence in the current and hypersensitivity to the active component of the drug or to any of its components, as well as a positive result of assay for the presence in urine of opioids. Do not take Vivitrol patients in opioid withdrawal.
Side effects Vivitrol
Some comments about Vivitrol says that with regular use of the drug in the treatment often appear vomiting, nausea, frequent bowel movements, abdominal pain, anorexia, increased or decreased appetite.
The instructions to Vivitrol indicate that intramuscular administration of medication can trigger the development of chronic lung disease, reflux disease, gastroenteritis, tooth abscess, ischemic stroke, pulmonary thrombosis, congestive heart failure, coronary artery atherosclerosis, pharyngitis, laryngitis, sinusitis, aneurysms of cerebral arteries, deep vein thrombosis.
In a review of medical and analogues Vivitrol Vivitrol
It states that adverse symptoms of these drugs may be shivering, lethargy, muscle twitching, sweating, headache, fainting, sedative state, impaired attention, irritability, taste perversion, anxiety and fatigue.
When the drug is administered at the injection site can occur pain, bleeding, swelling, itching.
Shelf life and storage conditions
Vivitrol stored in a place inaccessible to children at a temperature of 2 ° C to 8 ° C. Shelf life - 2 years. At room temperature, the preparation can be stored for more than seven days.