Veroshpiron - is a diuretic used against edema.
Pharmacological group: potassium-sparing diuretics.
International name is consonant with the active substance: Spironolactone.
Structure and Composition
Veroshpiron available in tablet form for 0, 025 g of active ingredient each. In one package of 20 and 100 tab.
The instructions to the drug veroshpiron described as potassium-sparing diuretic.
The main active ingredient is competing with aldosterone (a hormone of the adrenal cortex) and inhibits its action. Na +, Cl- and water is sucked back into the renal tubules, and K + and urea contrary to penetrate the vascular endothelium of the glomerular blood. Increased urination causes a decrease in blood pressure and loss of edema. The diuretic effect is only 3-5 days after the first day of dosing.
Veroshpiron not substantially affect the function of the renal tubules and leads to the acid-base imbalance organism.
- when edema associated with heart disease (chronic congestive heart failure), endocrine system (Conn disease, polycystic ovarian hirsutism);
- with hypertension;
- when ascites associated with cirrhosis of the liver;
- when the brain edema and other diseases that are accompanied by edema;
- in severe burns;
- In paroxysmal paralysis associated with calcium deficiency;
- myasthenia (as a means for adjuvant therapy).
Instructions for use and dose veroshpiron
Application veroshpiron possible only on prescription.
In cirrhosis daily dose sostavlyaet100 mg, 200 mg or 400 mg per day (the dose depends on the complexity of the disease).
In nephrotic syndrome, the daily dose is from 100 to 200 mg.
When edema take from 100mg / day. to 200 mg / day. three times a day.
Veroshpiron administer daily 5 days, then a daily dose is gradually reduced and brought to the 25 mg or 400 mg increases to 4 doses.
High blood pressure Veroshpiron administered 50-100 mg of agent per day, singly, or in 4 divided doses, for 2 weeks. The drug can be combined with antihypertensives.
When hypokalemia take 25-100 mg at a time, or up to 400 mg in divided doses.
In primary hyperaldosteronism Veroshpiron appoint 100, 200 or 400 mg per day in 4 divided doses before surgery and 25-50 mg for long-term treatment.
The syndrome of polycystic ovaries and hirsutism veroshpironom application is reduced to 100 mg twice a day.
Children appoint 1-3.3 mg / kg (30-90 mg / kg per day), taken singly or in 4 receptions. On day 5, the dose may be adjusted, if necessary, and a 3-fold increase.
On reaching effect veroshpiron dose is reduced to 0, 025 g per day, and then take 1 tab. Four times a day every 3 days.
In the opinion of veroshpiron drug may cause drowsiness, dizziness, indigestion, dermatitis, menstrual disorders and sexual function, lethargy, staggering when walking, muscle spasms, changes in the blood picture (megaloblastoz, thrombocytopenia, agranulocytosis).
In the opinion of veroshpiron patients, drug overdose is extremely rare.
In case of occurrence of side effects are aggravated all medicament. An urgent need to wash out the stomach, consume plenty of fluids and caffeine to increase blood pressure.
When hyperkalemia doctor prescribes insulin and dextrose.
The drug should not be taken at the kidney function, diabetes complications, hypersensitivity to any component of the drug, Addison's disease, raising the level of potassium and calcium in the blood, liver failure, pregnancy, gynecological diseases.
C Veroshpiron take caution when blockade of conduction in the heart muscle during surgery, taking hormonal drugs, anesthetics, in old age.
During the reception veroshpiron need to limit the intake of potassium and monitor kidney function and blood condition.
Instruction veroshpiron warns that the drug reduces the effect of anticoagulants, increases the effects of adrenaline, cardiac glycosides and lithium. Diuretics and corticosteroids in veroshpiron enhance the effect, and non-steroidal anti-inflammatory drugs - weaken its effect.
Veroshpiron should be stored in a cool place for up to 5 years.