Venofer - is a complex of ferric hydroxide and sucrose, which is used to correct iron deficiency states.
The main active ingredient Venofer: iron hydroxide.
Product: solution in ampoules of 5 ml and 2 ml (40 and 100 ml of iron) for intravenous administration. Each 1 ml of a solution of 20 mg of the active ingredient and sucrose.
Ferric iron, which is part of Venofer promotes the formation of heme (the main component of the blood protein hemoglobin). Besides drug gland regulates metabolic processes.
The instructions to the Venofer indicated that the drug is used:
- when iron deficiency condition that occurs as a result of intensive blood loss or complications of pregnancy in the third trimester;
- if necessary, rapid replenishment of iron deficiency before and after surgery;
- in the case of untreated iron preparations intended for oral or ineffective;
- in the case of erythropoietin therapy;
- iron deficiency in patients with rheumatoid arthritis;
- In case of problems the absorption of iron in the gastrointestinal tract.
Instructions for use Venofer
Venofer is administered only intravenously slow, bolus or infusion.
The drug is best administered the drip to reduce the risk of hypotension, and risk getting funds outside the walls of blood vessels.
Adults and elderly patients administered 5-10 ml Venofer (iron 100-200 mg) from 1 to 3 times per week.
Babies do not recommended to introduce more than 0, 15 ml of the drug solution (3 mg iron) with, based on 1 kg of body weight. The frequency of administration from 1 to 3 times per week.
Before infusion agent diluted with saline at a ratio of 1:20, and then injected at 100 mg iron per 15 minutes; 200 mg of material over 30 minutes; 300 mg of iron per 1, 5 hours; 400 mg of iron, and 2 and 5 hours; 500 mg - 3, 5 hours. The maximum single dose is 7 mg iron / kg and is administered for 3 to 5 hours, it does not depend on the daily dose.
Bolus. Venofer administered undiluted in / slow, 1 ml of 1 minute. The maximum amount of the drug for one injection - 10 ml. After the injection, the patient must at some time not to bend the arm.
Introduction Venofer in the dialysis system
the preparation is carried out as intravenous injection.
Dose calculation is carried out according to the formula: iron deficiency, mg = patient weight, kg × (Hb levels in normal - Hb levels present), g / l 0 × 24 (iron, which is in depot mg).
For patients weighing less than 35 kg: normal Hb = 130 g / liter, the iron level in the depot = 15 mg / kg.
For patients weighing more than 35 kg: normal Hb = 150 g / liter, the iron level in the depot = 500 mg.
If after 2 weeks after the start of therapy with no improvement is observed, it is necessary to revise the diagnosis.
Contraindications to the use of Venofer are:
- idiosyncrasy of iron and other components that are part of Venofer;
- first trimester of pregnancy;
- no iron deficiency anemia;
- cirrhosis of the liver in a state of decompensation;
- oversaturation of the body iron - hemochromatosis or hemosiderosis;
- acute infectious diseases;
- bronchial asthma;
- infectious hepatitis;
- states are related to violation of the synthesis of hemoglobin;
- polyvalent allergy.
If you follow the dosage indicated in the instructions for Venofer, the side effects of the drug occur rarely less 0, 01% and more frequently 0, 001%.
But, in the opinion Venofer may cause some cases of dyspepsia, dizziness, head pain, feeling of heat, lowering blood pressure, joint pain, back pain, swelling of the lymph nodes. In very rare instances, venous spasm, allergies and anaphylactic reactions.
Simultaneous administration of the drug with other drugs for the oral administration of iron leads to their excretion in the feces without absorption. Treatment with oral iron agents can start 5 days after the last dose Venofer.
The instructions to the Venofer indicated that the drug overdose occurs hemosiderosis.
Venofer administered with caution to patients with bronchial asthma, polyvalent allergy, eczema, allergic reactions iron supplements. In the opinion of Venofer it can complicate the course of liver disease, infectious disease, aggravate folic acid deficiency, and be effective for people who have low ability to bind serum iron.
Storage: The product is kept at a temperature of 25 ° C, in a dark place for up to 3 years. You can not freeze.
Divorced Venofer used within 12 hours.
Venofer is released from pharmacies by prescription.