Velcade

Velcade - means for inhibiting the growth of tumors.

 Velcade

Pharmacological action

The drugs work by suppressing the protein complexes of cell proteasomes.

The active substance Velcade - bortezomib.

Product form

Producing Velcade powder for preparation of intravenous solution.

Indications

Velcade is indicated for the treatment of mantiynokletochnoy lymphoma in patients who have been through treatment before.

There are reviews of Velcade, inhibits the growth of multiple myeloma.

Velcade Guide: how to use

Velcade is administered by intravenous bolus within 3-5 seconds.

Early treatment of drug administered in a dosage of 1 to 3mg sq.m. patient body surface. Enter Velcade two p / week for 2 weeks, then make a break of 10 days. During treatment, consider that between the two administrations Velcade must be at least 72 hours.

After it is passed three and five treatments were evaluated therapeutic result. If a satisfactory clinical response is obtained, hold two additional courses Velcade.

If a patient is scheduled to pass more than 8 courses, use the following scheme: the drug is administered weekly for a month, and do pereryv13 days.

If the clinical response after treatment was not followed or there is stabilization, the progress of the disease, prescribe high doses of Velcade with dexamethasone. Wherein dexamethasone is taken orally in a dosage of 40mg: 20mg daily administration Velcade and 20mg next day. In just three weeks administered 160mg of dexamethasone.

The instructions Velcade stated that in addition to monotherapy with combination therapy can be applied by combining the drug with prednisone, melphalan, which is taken orally. Thus, for multiple myeloma, has not been subjected to treatment is carried out before the six-week treatment cycles, with Velcade take two p / week, for the third and sixth week make a break. Melphalan and prednisone at the rate of 9 and 60 mg on sq.m. patient body surface, respectively, drink only in the first week of combined treatment, four days a week. Since the treatment is carried out first to fourth treatment cycle.

From the fifth to ninth cycles of treatment according to the instructions Velcade is administered once p / week for six weeks, taking a break in the third and sixth week. Melphalan and prednisone received at the same doses, and only during the first week of treatment, four days a week.

Dissolve the powder Velcade vials of 10 ml 3, 5 ml of sodium chloride solution 0, 9%, while the compliance with the rules upgrades, wear protective clothing and gloves to avoid contact with skin. With other drugs, and solvents should not be confused Velcade. Before the introduction of the solution Velcade inspected for discoloration and the presence of foreign inclusions.

Side effects of the drug Velcade

Velcade - a toxic drug and cause some serious side effects: anemia, leukopenia, neutropenia, lymphopenia, thrombocytopenia, cardiac arrest, heart attack, angina, cardiogenic shock, aggravation of chronic heart failure, pulmonary edema, ventricular hypokinesia and arrhythmia, reduced pressure, phlebitis, hematoma , bradycardia, intracranial hemorrhage, vasculitis, stroke, pulmonary hypertension, purpura, flushing, swelling of veins, cardiac tamponade, pericardial effusion, pulmonary embolism, dyspnoea, cough, hypoxia, bronchospasm, respiratory alkalosis, nasal congestion, tachypnea, rhinitis, chest pain and nasal sinuses, bloody sputum, acute respiratory failure, pulmonary hemorrhage.

There are reviews of Velcade, induce vomiting, constipation, nausea, abdominal pain, dry mouth, acute pancreatitis (rare), pain in the throat and throat, ileus paralytic, flatulence, diarrhea, belching, dysphagia, gastritis, enteritis, petechiae oral mucosa, excessive salivation, tongue coating, bleeding in the liver, liver failure, ischemic colitis (rarely), diarrhea, nausea, stomatitis, hiccups, headache, peripheral neuropathy, dizziness, syncope, paresis, convulsive activity, speech disorders, autonomic neuropathy, encephalopathy.  Bushings Velcade intravenously

Often, due to the treatment Velcade arise confusion, insomnia, anxiety, depression, delusions, hallucinations, mood swings, irritability, disrupted kidney, deteriorating eyesight, there is pain in the eyes, vertigo, muscle weakness and pain in the muscles and extremities, arthralgia, back pain. Often occurs dehydration, hyperglycemia, hypokalemia, decreased weight.

Hypersensitivity to Velcade, leading to allergic reactions occurs infrequently, but there are dermatologic reactions from the use of Velcade: rashes and itching, swelling of the eyelids and the area around the eyes, redness, dry skin, eczema, bruises, psoriasis, alopecia, dermatitis, change pigmentation, hair structure, the nodules may appear on the skin, swelling, fever.

In addition, there are patients from the reviews of Velcade, I feel during the treatment weakness, malaise, flu-like symptoms, pain in the groin.

Contraindications to the use of Velcade

Velcade should not be taken at the infiltrative and diffuse lung diseases, during pregnancy, lactation, with the defeat of the pericardium, hypersensitivity to the drug and to the forest.

The instructions Velcade stated that it can not be used in children.

Under constant surveillance by taking the drug, patients with impaired liver function severe and moderate, with severe kidney disease, epilepsy and convulsions, fainting, diabetic neuropathy in the past, and if there is the risk of chronic heart failure.

The bad reviews about Velcade, used for constipation and dehydration caused by diarrhea or vomiting.

With care prescribe Velcade simultaneously with the means, lowers blood pressure and oral medications that reduce blood sugar, with antiviral agents, amiodarone, isoniazid, a statin, nitrofurantoin, rifampicin and others similar to them by the action of drugs.





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