Tsiprinol

Tsiprinol - an antibacterial agent used for the treatment of infections caused by susceptible  Tsiprinol tablets
 the microorganism. Reviews tsiprinol prove its performance and high therapeutic activity.

Pharmacological action

Tsiprinol causes violation of DNA synthesis that leads to the cessation of growth and division of bacteria. According to the instructions tsiprinol particularly effective for the treatment caused by Gram-negative bacteria (Shigella, Klebsiella, E. coli, Salmonella, and others.) Diseases. This formulation is sensitive and a number of Gram-positive bacteria (Streptococcus, Staphylococcus), and intracellular bacteria (Chlamydia, Mycobacterium tuberkulezai etc.). In the opinion of tsiprinol it has the highest efficiency among all the other fluoroquinolones in infectious diseases caused by Pseudomonas aeruginosa.

The drug has a low activity against mycoplasma, anaerobic bacteria. It is not effective for fungal and viral infections.

If ingestion tsiprinol well absorbed. Eating slows down the absorption of the drug. The maximum content of active substance in the blood observed after half an hour after administration.

Application tsiprinol indicated for the treatment of diseases with intracellular localization of the pathogen, as it penetrates well into cells.

Withdrawal of the drug from the body is mainly done by the kidneys. The period of its half-life is 6 - 10 hours. Therefore, it can be used twice daily.

Form release tsiprinol

Tsiprinol produced as oblong white tablets and solutions for intravenous infusion.

Analogs tsiprinol

Medicines with a similar action with tsiprinol are Tsiprrosan, Tsipropan, Tsiprolon, Tsiprokvin, Tsiprovin, Tsiprobid, Tariferid, Sifloks, Renor, Perth, Oflomak, Oflotsid, Norilet, Norfatsin, Negafloks, Mikrofloks, maksakvin, Medotsiprin, lomefloxacin, Liprohin, Kvintor, Avelox and others.

Indications tsiprinol

  • Infections of the nose, throat, ear;
  • Respiratory tract infections;
  • Infections of the urinary organs;
  • Infections of the digestive system and bile ducts;
  • Soft tissue infections, skin and mucous membranes;
  • Infections of the musculoskeletal system;
  • Peritonitis;
  • Sepsis.

By tsiprinol instructions may be used for the treatment and prevention of infectious diseases in immunocompromised individuals, such as background immunosuppressive therapy.

Numerous analogues tsiprinol have exactly the same indications for use.

Contraindications

According to the instructions tsiprinol contraindicated in pregnancy, lactation and increased individual susceptibility to fluoroquinolones. Also, it can not be used to treat children and adolescents under 18 years of age.

Intravenous drug unacceptable in pseudomembranous enterocolitis and deficiency of glucose-6-phosphate dehydrogenase.

With great care tsiprinol appointed at various cerebrovascular disorders, epilepsy, mental illness, severe liver or kidney failure. It is undesirable to use tsiprinol elderly patients.

Side effects tsiprinol

When using tsiprinol may occur following side effects:

  • On the part of the digestive tract - abdominal pain, nausea, vomiting, loss of appetite, bloating, diarrhea;
  • CNS-headache and dizziness, insomnia, fatigue, increased intracranial pressure, tinnitus, diplopia, psychosis, hallucinations;
  • Allergic reactions - itching, and redness of the skin, urticaria. Anaphylaxis, reviews, tsiprinol is extremely rare;
  • Cardio-vascular system - tachycardia, hypotension;
  • On the part of the musculoskeletal system - muscle weakness, joint and muscle pain.

These side effects are typical for analog tsiprinol.

Cautions

If the treatment of the patient tsiprinol there is a long and severe diarrhea, it is necessary to exclude the development of pseudomembranous colitis requiring immediate lifting of the drug and administration of appropriate therapy.  The concentrate solution tsiprinol

In the opinion of tsiprinol can lead to severe inflammation and even tendon rupture. Therefore, when the first signs of tenosynovitis or when the pain in the tendons drug should be immediately abolished.

According to the instructions to tsiprinol patients during treatment should receive plenty of fluids, which allows to prevent the development of crystalluria.

In applying the drug should refrain from work requiring psychomotor speed of reaction and high concentration.

Dosage regimen tsiprinol

Tsiprinol recommended dose depends on the severity and localization of the infection, the general state of the organism, the body weight and age of the patient, renal function.

In diseases of the urinary and respiratory tract is usually prescribed at 250 mg tsiprinol twice a day. In complicated zabolevaniya- 500 - 750 mg twice a day.

For the treatment of uncomplicated gonorrhea drug is given a single dose of 500 mg.

In severe enterocolitis, prostate, gynecological infections and osteomyelitis tsiprinol appointed 500 - 750 mg every 12 hours.

The duration of treatment is determined by the severity of the disease.

Tablets should be taken strictly to food and drink plenty of fluids.

Overdose

In case of accidental or deliberate poisoning tsiprinol spend multiple gastric lavage. Since there is no specific antidote, symptomatic treatment.

Drug Interactions

Simultaneous use of theophylline and tsiprinol increases plasma concentration of the drug last.

The decrease of prothrombin index observed while taking tsiprinol and indirect anticoagulants, or oral hypoglycemic drugs.

Concomitant use tsiprinol and NSAIDs (except aspirin) significantly increases the risk of seizures.

According to the instructions tsiprinol should not be taken simultaneously with antacids, which reduce its absorption. Therefore, the interval between administration of these drugs must be at least four hours.

Combining tsiprinol with other antibacterial drugs leads to synergy.

Conditions of supply of pharmacies tsiprinol and storage

Tsiprinol refers to the list B and released from pharmacies only by prescription. It should be stored in a dark, dry place, away from children. Shelf life - 5 years.





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