International name - Cetirizine
Pharmacological action Tsetrina
Tsetrin - is an antagonist of histamine blocking H1 - histamine receptors
. The active ingredient - cetirizine
. Tsetrin shown as a prophylactic agent against allergic reactions, and to facilitate their flow
. It has antipruritic effect and protivoekssudativnoe
. It affects the allergic reaction in the early stages
. In the beginning stage of an allergic reaction medication limits the release of inflammatory mediators
. Tsetrin prevents swelling of the tissues, relieves spasms of smooth muscles, reduces the permeability of capillaries
. Eliminates skin reactions to specific allergens
. Do not have a antiserotoninovogo and anticholinergic action
. Subject to therapeutic doses, has practically no sedation
. After a single dose, beginning effect, about half of the patients is observed after 20 minutes, 1 hour, 95% of patients
. The effect of the drug lasts more than 24 hours
. In therapeutic treatment does not develop tolerance to the drug antihistaminergic
. After the treatment effect of the drug is stored up to 3 days
Tsetrin well absorbed in the gastrointestinal tract. Taking the drug with food has no effect on absorption. The maximum concentration of cetirizine in the blood occurs within 1 hour after drug administration and is 0, 3 mg / ml. To a small extent the drug metabolization in the liver. The half-life is about 10 hours in older patients up to 12 hours in children about 6 hours. The drug is released mainly in the urine.
Recommended application Tsetrina at:
- year-round and seasonal allergic rhinitis and conjunctivitis origin;
- urticaria, including chronic urticaria;
- hay fever;
- allergic dermatitis;
- skin ulcers;
- atopic asthma (in the complex therapy).
- Hypersensitivity to cetirizine;
When using Tsetrina persons with chronic renal failure, as well as elderly patients and children, caution should be exercised. On the treatment of children under one year Tsetrinom comments have been received.
Pregnancy and lactation
Like its counterparts Tsetrin not recommended for use when pregnant or breastfeeding.
Side effects may Tsetrina expressed as drowsiness, dry mouth, at least in the form of headaches, dizziness, headaches, disorders of the gastrointestinal tract, allergic reactions.
Symptoms of overdose can occur when single dose of 50 mg doses. Overdose appears dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability. It is treated by gastric lavage, symptomatic treatment. There is no antidote. The effectiveness of hemodialysis has not been confirmed.
Tsetrina Dosage and instructions for use
Tsetrin taken orally as a tablet washed down with water soluble as droplets in water.
The dosage for children older than 6 years and adults - 1 times a day 10 mg or 2 times a day for 5 mg. Babies ranging from 2 to 6 years, half the adult dose. Services from one to two, two times a day for 2, 5 mg (5 drops). In patients with reduced renal function 5 mg - once daily. In severe forms of chronic renal failure, Tsetrin shows 5 mg once per 48 hours.
According to the reviews Tsetrin in doses greater than 10 mg per day, can influence the reaction speed. In connection with this instruction Tsetrin advised to be particularly careful at the time of treatment, persons driving. Within the recommended doses does not potentiate the effect of ethanol. However, it is not recommended the use of ethanol in the period Tsetrina analogue therapy.
It was not found any significant pharmacokinetic interaction Tsetrina cimetidine, pseudoephedrine, azithromycin, glipizide, ketoconazole, diazepam, erythromycin.
The simultaneous use of theophylline results in a decrease in clearance of cetirizine without altering the kinetics of theophylline.
Tsetrin stored in a dry, dark place, away from children. Store this medication at room temperature not exceeding 25 ° C.