Tsefekon - antipyretic
and an anesthetic.
Pharmacological action Tsefekona
The drug belongs to a group of non-narcotic analgesics. The structure includes Tsefekona active substance paracetamol. Its mechanism of action by blocking the enzyme cyclooxygenase on thermoregulation center level in the brain. This reduces the production of prostaglandins - substances that cause inflammation and thermoregulation threshold returns to normal levels. With this Tsefekon has antipyretic and analgesic action, do not alter the normal body temperature. The cell tissue destroying enzymes peroxidase paracetamol, so it is an anti-inflammatory effect is negligible.
Application Tsefekona not retained in the body excess water and sodium ions has no adverse effect on the mucous membrane of the stomach and intestines.
Because rectal suppositories of paracetamol absorption occurs in the arterial network of the rectum. The maximum concentration of drug in the blood accumulates after 0, 5 - 1 hour. He is able to penetrate the blood-brain and placental barriers.
Converting drugs into inactive metabolites in the liver. Compared with peers Tsefekona oral with rectal it arrives first pass liver passage of paracetamol. With this drug load on it in such a method of administering reduced. Excretion of the drug metabolites occurs via the kidneys in the urine.
Tsefekon instructions for producing a rectal suppository containing 50, 100 or 250 mg of paracetamol.
The drug is used in children aged 3 months to 12 years to reduce the body temperature in the case of acute respiratory diseases and childhood diseases (measles, chicken pox, scarlet fever), with fever in the post-vaccination period. It helps to eliminate unpleasant accompanying symptoms such as headache and muscle pain.
There are good reviews about Tsefekone as an analgesic during teething.
Do not use the drug for his personal intolerance, inflammation of the rectum or bleeding from her children under the age of 1 month.
To use caution in pathology Tsefekon forming organs (anemia, neutropenia), congenital deficiency of glucose-6-phosphate dehydrogenase.
Despite the fact that the composition Tsefekona safe for use in children at an early age, for reducing the temperature after the vaccination at the age of 1 to 3 months, it is used once only under medical supervision.
Instructions for use Tsefekona
inserted into the rectum after discharge or enema. Rectal form is especially useful for young children who have difficulty swallowing medication at or if the disease is accompanied by vomiting.
The dosage depends on the child's age and body weight. On average it is 10 - 15 mg / kg / day, an interval between the application of the suppository is 4 - 6 hours.
Single dose: children from 1 to 3 months inserted suppositories of 50 mg, from 3 to 12 months are suitable rectal suppositories at a dosage of 100 mg, 1 to 3 years, and 1 - 100 mg suppository 2, 3 to 10 years - 250 mg from 10 to 12 years: 2 250 mg of the suppository.
The maximum tolerated dose of 60 mg / kg / day. Share suppository can not because of possible unequal distribution of paracetamol at its core.
As antipyretic without consulting a doctor for instructions Tsefekon used for no longer than 3 days, as an anesthetic - up to 5 days. The physician may prolong the course if necessary.
Tsefekon undesirable to use in conjunction with salicylates - possible toxic damage to the kidneys. The drug enhances the effect of anticoagulants.
In the opinion of Tsefekon can cause allergic reactions, nausea, abdominal pain, decrease in hemoglobin, platelet and white blood cell count.