Tropikamid

Tropikamid - drug presented in the form of eye drops.

Active  Eye drops Tropikamid
 substance - tropicamide (5 mg). Excipients: sodium chloride (7 mg), disodium ethylenediaminetetraacetate (0, 5 mg), benzalkonium chloride, 50% (0, 2 mg), hydrochloric acid, water for injection.

The pharmacological action of tropicamide

The pharmacological action of tropicamide - holinoliticheskoe, mydriatic. The drug causes paralysis of accommodation, mydriasis (pupil dilation), contributes to blocking m-cholinergic receptors. On responses to tropicamide, the drug is less than the atropine paralysis of accommodation and has a weaker effect on intraocular pressure. Nevertheless, the application of tropicamide by instructions capable to a certain extent to cause its increase, which should be considered for patients suffering closure glaucoma.

Action tropicamide develops after 5-10 minutes after instillation, reaching its maximum in 15-20 minutes. Mydriasis (at 0, 5% solution) is maintained for 1 hour by using a solution of 1% - 2 hours. Paralysis of accommodation (after the instillation of 1% solution) is kept for 30 minutes. The optimal time for eye research - 30-40 minutes (using 0, 5% solution) and 25-30 minutes after repeated instillation of 1% in the solution. Full completion of paralysis of accommodation possible after 3 hours after instillation.

Tropikamid and analogues of the drug is well absorbed into the systemic circulation, making possible the emergence of systemic side effects which, in the opinion to tropicamide mainly observed in infants and in the elderly patients.

Testimony

According to the instructions assigned Tropikamid in research lens of the eye fundus, the determination of refraction. The drug has been used successfully in surgical practice (the operations in the vitreous, retina, retinal photocoagulation) in the treatment of inflammatory diseases of the eye, as well as complex therapy as prophylaxis for the appearance of postoperative adhesions.

Contraindications

Mixed and angle-closure glaucoma, hypersensitivity to the components of tropicamide. Use of the drug during pregnancy and breastfeeding is not desirable, however, possible if the expected effect of using tropicamide exceeds the potential hazard to the child's development.

Side effects tropicamide

The consequences of tropicamide  Packing Tropikamid
 may be local disturbances: decreased visual acuity, acute attack of angle-closure glaucoma, increased intraocular pressure, fear of light, as well as systemic reactions, which are, in the opinion to tropicamide, manifestations of anxiety, dry mouth, agitation, hyperthermia, dysuria, tachycardia.

When haphazard use tropicamide without instruction may be overdosing. Antidote agents are beta-blockers, benzodiazepines, physostigmine salicylate (at a dose of 0, 03 mg / kg by slow intravenous injection).

When taken intravenously tropicamide may develop severe drug addiction.

Tropikamid and analogues

Analogues are tropicamide eye drops Midriatsil, Midrum used for the diagnosis and treatment of diseases of the eyeball.

Cautions

According to the instructions Tropikamid be instilled into the lower conjunctival sac. During treatment should refrain from driving vehicles and Occupation potentially hazardous activities that require prolonged concentration and speed of reaction. On responses to tropicamide wearing contact lenses while using drugs can have unwanted consequences.

When receiving non-medical intravenous tropicamide experience the following symptoms: confusion, agitation, hallucinations appearance. The consequences of the introduction of the drug tropicamide injecting extremely serious: yellowing of the skin, a sharp drop in hemoglobin, unrecoverable loss of vision (including blindness), seizures. Administered intravenously Tropikamid leads to heart disease, pain in the muscles and internal organs, tissue detachment from the skeleton, loss of memory, madness, degradation of brain and requires immediate comprehensive treatment for drug addiction.





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