Tolterodine - a substance that is a competitive blocker of m-cholinergic receptors, and which is part of the drugs used in the treatment of urological diseases.
The pharmacological effects of the drug tolterodine
Included in the various drugs tolterodine substance antagonizes m-cholinergic receptors, which are localized in the salivary glands and bladder, has holinoliticheskoe and antispasmodic effect.
The active 5-hydroxymethyl derivative of tolterodine is highly specific for muscarinic receptors, has no effect on the other receptors, and has, in contrast to the receptors of the salivary glands, the selectivity for receptors of the bladder.
According to the instructions tolterodine, which is part of antispasmodic drugs, not only reduces the activity of the bladder, but also reduces the detrusor pressure and salivation, contributes to the weakening and disappearance of incontinence and increase the interval between urination.
According to the instructions tolterodine part of the preparations Detruzitol, Urotol and Debye- issued in the form of tablets and capsules.
Analogs of tolterodine
Detruzitol, Urotol Debye- and are analogues of tolterodine-containing preparations of the active substance. For analogs containing tolterodine drugs mechanism of action, and of belonging to the same pharmacological group includes medications:
Indications for use of tolterodine
According to the instructions tolterodine is prescribed for the treatment of overactive bladder, which manifests itself in the form of urinary incontinence or frequent urination mandatory.
In accordance with the instruction tolterodine containing drugs taken orally 2 mg twice a day. In the presence of hepatic or renal insufficiency in a patient, and the development of side effects, the dose was reduced by half (1 mg twice a day). The duration of treatment with drugs containing tolterodine is from three to six months.
In accordance with the instructions tolterodine is contraindicated in case of hypersensitivity to the substance, urinary retention, intractable treatment of myasthenia gravis, angle-closure glaucoma, severe ulcerative colitis and megacolon.
Side effects of tolterodine
The use of drugs, which include the substance of tolterodine reviews causes side effects of the various systems of the body, namely:
- Blurred vision, dizziness, headache, xerophthalmia, drowsiness and fatigue (the nervous system and sense organs);
- Hypertension (cardiovascular system);
- Dry mouth, nausea, indigestion, constipation, flatulence, diarrhea and abdominal pain (gastrointestinal tract);
- Urinary tract infection and dysuria (urogenital system).
Also, drugs containing tolterodine on responses cause allergic reactions and flu-like symptoms, weight gain, sinusitis, bronchitis, and skin dryness.
The combined use of tolterodine with anticholinergic agents enhances the therapeutic effects of the drug and increase the risk of side effects. The combined use of tolterodine with muscarinic cholinergic receptor agonist reduces the effect of the substance.
In parallel with the use of tolterodine fluoxetine observed significant inhibition of metabolism of tolterodine in extensive metabolizantov.