Thiamine - is a water soluble vitamin B1, which is used to compensate for the deficit in the body, and for the treatment of diseases.
The pharmacological action of Thiamine
In the body Thiamine turns into coenzyme kokarboksilazu. It is part of many enzymes that catalyze biochemical reactions. By cocarboxylase vitamin plays an important role in carbohydrate, protein and fat metabolism. Thus regulating metabolism, it has a positive effect on the whole organism in various pathological processes.
Thiamine peculiarity is its ability to influence the conduct of neural excitation in the synapses, improving it. This is possible because of the change in the polarization of membranes in the neuromuscular junction, so that is a moderate ganglion-blocking action. Vitamin B1 is also able to protect cells from damage by oxygen radicals, that is, exhibits antioxidant properties.
The product after falling into the blood is widely distributed in tissues, about half of its falls into the muscle. Withdrawal is carried out with the feces and urine. As the water-soluble vitamin, it is unable to accumulate in the body and rapidly excreted.
Thiamine instructions for producing a solution for injection, capsules and tablets.
Thiamine is used according to the instructions to fill in the body of the deficit in the increased demand for it, insufficient intake or excessive loss, as well as for the treatment of certain diseases.
Deficient Thiamine is called hypovitaminosis B1, and its absence - B1 vitamin deficiency (beriberi).
The drug is part of the scheme of treatment of diseases of the nervous system - neuritis, polyneuritis, radiculitis, peripheral paresis and paralysis, neuralgia.
In dermatology, vitamin B1 is used for neurogenic dermatoses, itching of the skin, pyoderma, psoriasis, eczema.
Thiamine received good reviews in the complex treatment of diseases of the digestive system - gastric ulcer and duodenal ulcers, intestinal, liver diseases.
With long-term physical and mental strain, during pregnancy and lactation, in patients on hemodialysis need for vitamin B1 rises sharply, and requires replenishment from the outside.
Thiamine is not appointed according to the instructions in its intolerance, if it has been registered before.
Instructions for use Thiamine
Methods of administration are different - in and parenterally (intramuscularly, subcutaneously, intravenously).
For oral administration in the form of thiamine chloride adult dosage is 10 mg of 1 - 3 times a day, children younger than 3 years - 5 mg every other day, from 3 to 8 years - 5 mg 3 times a day, a day, a course of 30 days.
If necessary, more rapid saturation of the body of thiamine chosen parenteral route of administration. The drug is administered one time per day, 1 ml for adults and children over 0, 5 ml, the rate is between 10 and 30 injections. Because of the low pH of the parenteral injection painful.
You can not simultaneously administered parenterally vitamins B1, B6 and B12 - this will reduce the effect of the drug and increase the likelihood of an allergic reaction. The use of thiamine and nicotinic acid in the same syringe impossible.
In the opinion of Thiamine is well tolerated, but sometimes can cause allergic reactions such as urticaria, angioedema, pruritus, rarely - anaphylactic shock. For parenteral administration, reactions are stronger than when taken orally. Also there sweating and palpitations.