Vincristine

 Vincristine formula

Vincristine - alkaloid plant remedy, a drug used for the treatment of malignant tumors.

Pharmacological action

Vincristine - is an antineoplastic agent, an organic compound of a pink vinca ability to block metaphase of cell division, and in high doses to stop the production of proteins and nucleic acids.

Product form

Producing Vincristine as a lyophilisate for solution for I / governmental injections.

The solvent is typically bundled with ampoules.

Indications

Vincristine is prescribed for acute leukemia, a combined therapy of acute lymphoblastic leukemia in children for the treatment of non-Hodgkin's malignant lymphomas, multiple myeloma, Ewing's sarcoma, soft tissue sarcoma, osteogenic sarcoma, Kaposi's sarcoma, uterine sarcomas, rhabdomyosarcoma (including fetal).

According to the instructions Vincristine is also used in cancer of the renal pelvis, ureter, bladder, breast, cervical, small cell carcinoma, melanoma, tumor Williams, neuroblastoma, germ cell tumors of the testicles, ovaries, ependimiome, pleurisy tumor origin horionepitelioma uterine malignancies in Girls on the genitals, idiopathic thrombocytopenic purpura (resistant to glucocorticosteroids, and in cases when splenectomy has not given effect).

Instructions for use Vincristine

 Vincristine

The drug Vincristine is administered intravenously at weekly intervals. The treatment regimen is prescribed strictly individually.

The average weekly dose of instructions Vinkristina- 0, 4-1, 4 mg / m. body for adults. Children appoint 2mg / m. body.

Vincristine is administered in the cavity between the shells lung - 1 mg of the drug dissolved in physiological saline (10ml).

Side effects of Vincristine

Known side effects such Vincristine: insomnia, muscle weakness, hair loss, numbness in the limbs, impaired movement, constipation, fever, weight loss, reduction in the number of leukocytes in the blood.

Rarely, but there are plenty of urination, inflammation of the oral mucosa, dysuria, loss of appetite, vomiting, nausea as a side effect Vinikristina.

Also, the drug vincristine neurotoxicity, it has a negative impact on the nervous central system, which should be considered when treating the elderly and those who have previously observed neurological diseases.

The frequency and severity of side effects associated with Vincristine treatment duration and dose of the drug obtained.

Contraindications

Vincristine sulfate solution is not used simultaneously with a solution of furosemide.

The product has a strong irritant, so avoid contact with the skin, eyes, due to the high probability of tissue necrosis.

Vincristine is not appointed at a high sensitivity to vinkoalkaloidam, acute infectious diseases, fungal, viral, bacterial origin. As well as in severe bone marrow suppression, with neurodystrophic diseases during pregnancy, lactation.

With careful use of vincristine mechanical jaundice, hyperbilirubinemia, suppression of bone marrow hematopoiesis after radiation therapy in the area of ​​the spinal cord and the hepatobiliary region, against the backdrop of hyperuricemia, with liver failure.





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