Terbinafine

Terbinafine - antifungal agent with broad spectrum allylamine.

The drug is available in two dosage forms in the form of ingestible tablets and as an agent for external application.  Terbinafine cream

Terbinafine 1 tablet contains 250 mg of active substance terbinafine and auxiliary elements: starch, microcrystalline cellulose, sodium methyl paraben, povidone, sodium lauryl sulfate, magnesium stearate, sodium starch glycolate, colloidal silicon dioxide, talc.

Pharmacological action

According to the instructions, Terbinafine is able to exert a therapeutic effect on a wide range of fungal infections which cause diseases of hair, nails, skin, including dermatophytes (T.rubrum, T.tonsurans, T.mentagrophytes, T.violaceum, T.verrucosum, Microsporum) and yeast-like fungi Candida (eg, Pityrosporum, Candida albicans) and agents of multi-colored lichen.

The therapeutic effect of the drug is due to the oppression of squalene epoxidase, located in the cell membrane of the fungus. Terbinafine results in the accumulation of squalene in the cells and a deficiency of ergosterol biosynthesis at an early stage, the cells of the pathogen that causes her death.

If ingestion Terbinafine is well absorbed from the gastrointestinal tract, creating high concentrations of the active substance in the nails and the hair follicles. During the first weeks of released terbinafine in sebum, it accumulates in the lipophilic stratum corneum layer in an amount sufficient to provide a fungicidal action of the drug. The active ingredient of the drug is excreted in urine as metabolites.

Indications for use Terbinafine

According to the instructions Terbinafine appointed inside with:

  • Onychomycosis - nail fungal infections caused by dermatophytes;
  • Mycosis of the scalp;
  • Tinea shins, scalp, feet, torso, as well as yeast infections caused by fungi Candida - in cases where the severity of the infection determines the reasonableness of oral therapy.

Terbinafine in the form of a cream is effective in each of the aforementioned diseases. In addition, according to reviews of terbinafine may be noted that taking the drug in pill form is not able to eliminate the fungal infection of the skin such as the multi-colored shingles.

Contraindications

Contraindications to terbinafine include hypersensitivity to the active substance and other ingredients. Also, according to the instructions of terbinafine dosage should be avoided during pregnancy and lactation.

In the treatment of drug recommended precautions. If in the course of therapy the patient has nausea, lack of appetite, vomiting, pain under the right rib, unexplained fatigue, and discolored feces and dark urine, you should immediately consult your doctor to confirm the hepatic origin of these symptoms and stop taking Terbinafine.

Terbinafine and analogues of the drug should be used with caution for people suffering from kidney and liver failure, metabolic disorders, alcoholism, occlusive diseases of extremities, as well as children under the age of 12.

So far, in a review of terbinafine were reported to the presence of fetal malformations in the application of the drug in pregnant women. However, to carry out treatment with terbinafine in this position is not recommended - due to insufficient research.

At the same time taking oral contraceptives and Terbinafine possible disruption of the menstrual cycle.

side effects

Terbinafine, in the opinion of patients, causes disturbances of various body systems. From the digestive system there are anorexia (not eating), nausea, diarrhea, jaundice, cholestasis, hepatitis. Hematopoietic system - thrombocytopenia, neutropenia. In addition, the receiving Terbinafine may provoke headaches and local allergic reactions: skin rash, pruritus, myalgia, arthralgia, Stevens-Johnson syndrome, erythema multiforme.  Terbinafine tablets

According to studies, side effects in terbinafine occur only in 3-5% of patients, and discontinuation of therapy usually is not required.

Terbinafine and analogues

Terbinafine analogues of the active substance are drugs such as Atifin, Lamisil, Lamikan, Mikonorm, Onihon, Terbizil, Terbinoks, Termikon, Ungusan, Tsidokan, Ekzivin and some others, have similar therapeutic effect with respect to dermatomitsetami and yeasts.

Dosage Terbinafine

Single dose receiving terbinafine tablets depends on body weight and equals:

  • For children weighing less than 20 kg - 62 mg of 5;
  • 20-40 kg - 125 mg;
  • Over 40 kg - 250 mg.

Terbinafine in the form for external use is used one time per day for 1-2 weeks, depending on the nature of the disease. Before applying the cream affected areas should be clean and dry. Terbinafine is rubbed with a thin layer on the skin and the surrounding areas. In the treatment of diaper rash between the buttocks, in the interdigital spaces, under the breasts place applying the cream is recommended to cover a layer of gauze.

The duration of treatment with terbinafine and analogues of the drug depends on the severity of the disease and the presence of comorbidities. If within 2 weeks after receiving instructions by Terbinafine no improvement, you need to determine the sensitivity of the pathogen to the means employed. It should be remembered that the early termination of treatment can lead to relapse.

This manual is not intended to terbinafine for self-treatment. Before taking this medication, consult your doctor.





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