Telfast

Telfast - means for treating allergic diseases.

Pharmacological action

Telfast is the first third-generation antihistamine and deprived many of the side effects of the previous two generations.  Telfast tablets (120 mg)
 The main component of the preparation - fexofenadine, which is the active metabolite of terfenadine, thanks etomuon has a 2-fold greater affinity for histamine H1-receptors. Telfast highly selectively binds to H1 receptors, and blocking them, does not manifest biological effects of histamine in the form of symptoms of allergic diseases (allergic dermatitis, runny nose, sneezing, watery eyes, itchy skin, etc.). The drug can somewhat stabilize mast cell membranes, preventing and reducing the release of these biologically active substances, especially histamine.

Unlike their counterparts Telfast misses the blood-brain barrier to the brain, so no sedative properties. It has no effect on the rate of reaction and mental ability to concentrate, for example, by driving the transport or during the study. Telfast for instruktsiine addictive even at long application.

The study of the drug was conducted as invitro, as well as in a clinical setting, and everywhere he confirmed the high efficiency. It was shown that compared with their counterparts Telfast no effect on other receptors, including histamine N1- species and H2 receptors. He does not have anticholinergic activity antiadrenergicheskim and therefore side effects from the stimulation of other types of receptors are absent.

Telfast does not change the slow potassium currents, so does not affect the electrophysiology of the heart - the QT interval on the electrocardiogram did not change during treatment. The lack of cardiotoxicity makes it an alternative to terfenadine.

The drug is rapidly absorbed, its therapeutic effect occurs within 1 hour after oral administration, reaching maximum strength after 6 hours. The total duration of Telfasta instructions amounts to little more than 24 hours, because of this it can be taken one time a day. Strength of it is a linear function of the dose. The drug is practically not metabolized in the body and excreted unchanged in the feces (80%) and urine (10%).

Product form

The drug is available in tablets of 30 mg (children form), 120 mg and 180 mg.

Indications Telfasta

Telfast of instructions recommended for the treatment of allergic diseases such as seasonal allergic rhinitis and hay fever, allergic and chronic idiopathic urticaria, angioedema (angioedema).

Contraindications

Do not take the drug for the individual of his intolerance during pregnancy and lactation. Reviews of Telfast in children under 6 years are not available, because the drug is not recommended for them. Precautions should take it in the pathology of the liver and kidneys.

Instructions for use Telfasta

The drug is taken orally 1 time a day, drinking plenty of water. While the food and does not affect the flow of drugs into the bloodstream, it is advisable to take it before meals. Simultaneous treatment with antacids slows absorption Telfasta because between them should be an interval of at least 2 hours. Studies have shown that elderly patients do not require dose conversion towards its reduction or extension of the interval between doses.  Telfast tablets (180 mg)

For the treatment of seasonal allergic rhinitis, since the age of 12, it is recommended to take 1 120 mg once a day, in the case of chronic idiopathic urticaria and angioedema of 180 mg 1 time per day. Children from 6 to 12 years Telfast appoint 30 mg 1 time a day. Duration of individual is determined by the attending physician. Possible long-term use Telfasta to 4 - 6 weeks.

Side effects Telfasta

In the opinion of Telfast well tolerated, occasionally there are headaches, dizziness, nausea. Very rarely recorded cases of shortness of breath, skin flushing and anaphylactic reactions.





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