Tamiflu - an antiviral agent.
Release form, packaging and composition of Tamiflu
The drug is available in hard gelatin capsules with an opaque housing, and as a powder for suspension.
The contents of one capsule - white or yellowish powder containing 98, 5 mg of active substance (oseltamivir phosphate) and auxiliary components (Povidone K30, pregelatinized starch, sodium koskarmellozu, talc, sodium stearyl fumarate).
Powder for oral suspension and is presented in granular form of white or yellowish in color with a fruity odor. One gram of the medicament contains 39 mg of oseltamivir phosphate 4 and auxiliary substances (titanium dioxide, sorbitol, sodium benzoate, monosodium citrate, sodium saccharin, permasil 11900-31 Tutti Frutti). The final suspension formulation contains 12 mg / ml of active ingredient.
According to the instructions, Tamiflu is a prodrug. Its active ingredient, oseltamivir phosphate competitively inhibits neuraminidase influenza viruses type A and B - an enzyme that promotes the breakdown of the relationship between sugar and terminal sialic acid. Neuraminidase inhibition prevents the virus epithelial mucus than is its distribution in the airways. The action of the drug Tamiflu and analogues based on the selective inhibition of neuraminidase inhibition of growth and replication of viruses. In the opinion of Tamiflu reduces the period of manifestations of influenza infection, reducing the severity of the disease and reducing the frequency of complications of the disease (pneumonia, bronchitis, otitis media, sinusitis). The drug has no effect on the formation of antibodies after injection of influenza vaccine.
After application of the active ingredient of Tamiflu medication oseltamivir phosphate completely absorbed from the gastrointestinal tract and converted to an active metabolite by the action of esterases that are predominantly in the intestine and liver. The further transformation of the active metabolite is not exposed, and excreted in the urine.
The drug is effective in the treatment of influenza A and B in adults and children one year of age.
In addition, the review notes to Tamiflu good preventive effect of the drug in adults and adolescents who are at high risk of infection (in large groups, in military units, in debilitated patients).
As contraindications to the use of Tamiflu note hypersensitivity to the drug, hepatic failure (chronic peritoneal dialysis, continuous hemodialysis). Tamiflu treatment during pregnancy and lactation and in children is not recommended.
As a side effect of careless use of Tamiflu, according to instructions, there are nausea, vomiting, diarrhea, dyspepsia, abdominal pain. The respiratory system can occur cough, bronchitis, runny nose. Disturbances in the central nervous system characterized by headache, dizziness, weakness. Side effects of the drug in children, most often manifested as vomiting, nosebleeds, nausea, asthma.
On responses to Tamiflu in some patients, there were cases of seizures and neuropsychiatric disorders, but similar symptoms were reported as suffering from flu patients who were not taking Tamiflu.
Use of Tamiflu during pregnancy
Data for receiving Tamiflu during pregnancy collected enough: so the drug should be administered during the childbearing and breast-feeding only if the expected benefits from its use outweigh the risks for the development of the fetus and the health of the child.
Tamiflu and analogues
By analogues of Tamiflu - drugs suppressing the reproduction and distribution of influenza virus types A and B, and include Arbidol Amiksin.
The therapeutic effect of Arbidol is based on the enhanced development of interferon, which enhances human immunity at the cellular level.
Amiksin also inhibits the development of the virus, causing the body to intense division of stem cells, gently and effectively eliminating the disease. As a side effect for both drugs may include allergic reactions, however, are more serious violations in the work of the body by careless reception of medicines have been identified.
According to the instructions, Tamiflu should be stored at a temperature no higher than 20-25 ° C, without exceeding the expiry date - 7 years. The drug is released from pharmacies by prescription.