Zoeli - it
Innovation combined, monophasic, mikrodozirovanny oral drug that contains hormones similar to the natural.
Release form and composition
Zoeli is available as film-coated tablets which are white, round and biconvex shape. The tablets are engraved Zoeli «ne» on both sides.
The active ingredients of tablets Zoeli - estardiola hemihydrate and nomegestrola acetate. As auxiliary substances are present, microcrystalline cellulose, magnesium stearate, crospovidone, lactose monohydrate, and colloidal silicon dioxide.
Placebo tablets are yellow, round bi-convex shape and the engraving 'p' on both sides.
Estradiol is the natural estrogen that is identical to the endogenous human 17β-estradiol (E2). E2 has no methyl group in the 17α-position in contrast to ethinylestradiol which is part of the other combined oral contraceptives.
Nomegestrola acetate is a highly selective progestogen, which is like the natural steroid hormone progesterone, and has a similar structure to it. It has a high antigonadotropnym activity, moderate anti-androgenic activity and has no estrogenic, androgenic, mineralocorticoid and glucocorticoid activities.
Tablets Zoeli have contraceptive effect through the combination of various factors, the most important of which are changes in the secretion of cervical mucus and suppressing ovulation. After the cancellation of tablets Zoeli ovulation in most women recover quickly enough.
Dosing and Administration Zoeli
The drug is taken orally. According to the instructions, Zoeli should be taken every day at the same time, regardless of the food in accordance with the procedure described in the instructions. If necessary, you can wash down with a little water.
According to the instructions, Zoeli take one pill a day for 28 days. During the first 24 days of a white tablet, the following 4 days - yellow, which do not contain active substance. Usually, two or three days after the last white tablet Zoeli begins withdrawal bleeding, which can not stop before you start taking the tablets in the next pack.
Side effects Zoeli
According to the instructions, Zoeli tolerated quite well.
Metabolism can be observed an increase in body weight, fluid retention and increased appetite, very rarely - decreased appetite.
From the side view: very rarely - dry eyes and contact lens intolerance.
From the nervous system: headaches and migraines, very rarely - a violation of attention.
On the part of the mind, depression, decreased libido, mood swings, very rarely - increased libido.
From the vessels: Infrequent - tides.
For the skin: acne infrequently - alopecia, dry and itchy skin, rash, seborrhea, very rarely - hypertrichosis and chloasma.
From the digestive tract: nausea, rarely - increase in liver enzymes, abdominal distension, very rare - dryness in the mouth.
breast and genital organs: metrorrhagia, pain in the breast, irregular withdrawal bleeding, pain in the small pelvis, infrequently - breast engorgement, gipomenoreya, uterine spasm, seals in the mammary glands, premenstrual syndrome, vaginal dryness and vulvar dyspareunia, very rarely - discomfort in the vagina, an unpleasant odor from the vagina.
From the musculoskeletal system: rarely - a feeling of heaviness.
Common side effects: rarely - swelling and irritability, very rarely - a feeling of hunger.
Application Zoeli tablets should be discontinued in the event of:
• Deep vein thrombosis and pulmonary embolism, including a history;
• Migraine with focal neurological symptoms, including a history;
• arterial thrombosis (myocardial infarction, circulatory disorders in the brain) or prodromal state (angina pectoris, transient ischemic attack), including the anamnesis;
• expression or multiple risk factors for arterial or venous thrombosis (diabetes mellitus with vascular symptoms, severe hypertension, severe dyslipoproteinemia);
• severe hypertriglyceridemia, pancreatitis, including the anamnesis;
• Hepatic tumors (benign or malignant), including the anamnesis;
• severe liver disease;
• Vaginal bleeding for unclear reasons;
• postmenopausal women;
• Lactose intolerance and lactase deficiency.
According to the instructions, Zoeli also can not be taken during breastfeeding and hypersensitivity to any component of the formulation.
Reviews Zoeli talking about the safety of its use. According to most reviews, Zoeli well tolerated as a small dose of hormones that are identical to natural.