Tutabin - a medicament having antitumor activity and is used to treat certain cancers. Its main active substance is capecitabine.
Pharmacological action Tutabina
Tutabin has a selective cytotoxic effect. Once in the tumor cells, it is under the action of the tumor angiogenic factor (timidifosforilazy) is converted to 5-fluorouracil. Activity in tissues of malignant tumors thymidine several times higher than in healthy cells of tissue or blood. Therefore, the concentration of 5-FU which is 4 times higher. The further metabolism of 5-FU formed ftorurdina 5-triphosphate and 5-fluoro-2-deoxyuridine monophosphate has potent cytotoxic effects.
According to the instructions, Tutabin used to treat breast cancer, including those with distant metastases. This medicine can be used in patients who have contraindications to treatment with anthracyclines. According to reviews, Tutabin in some cases is effective for the treatment of malignant tumors refractory (resistant) to the drugs paclitaxel and anthracycline group.
Tutabin: instructions for use
Receive Mode and dispensing pills Tutabin doctor individually set for the type of tumor, the scheme anticancer therapy, stage of disease, the state of the hematopoietic system.
In the standard scheme of tablets Tutabina appointed at the rate of 2, 5 g of active ingredient per square meter of the patient's body. The daily dose is divided into two steps and take half an hour after the meal. Duration of treatment - 14 days, after a week's break, it can be extended.
Tutabina Dosage may be reduced when poor tolerability.
According to the instructions, Tutabin contraindicated in the following cases:
- High individual sensitivity to the components of the drug;
- Severe hepatic impairment;
- Dihydropyrimidine dehydrogenase deficiency;
- Pregnancy and lactation;
- Patient age younger than 18 years.
The tablets should not be administered simultaneously Tutabin with Sorivudinom or brivudine, as well as their structural analogues.
According to reviews, Tutabin with great care should be used in the treatment of patients suffering from renal failure, coronary artery disease receiving coumarin anticoagulants. When assigning tablets Tutabina elderly should regularly monitor the condition of the hematopoietic and coagulation systems, as well as once a month to perform an ECG, since cardiotoxic drug has.
Side effects Tutabina
The instructions to Tutabinu noted that the use of the drug may lead to side effects of the various organ systems:
- From the gastrointestinal tract: stomatitis, epigastric pain, taste disturbance, hyperbilirubinemia, oral candidiasis, loss of appetite, bloating, dry mouth, constipation or diarrhea, nausea, vomiting;
- From the nervous system: fatigue, insomnia, dizziness, paresthesia, headache, weakness, fatigue;
- For the skin: cracks and / or hyperpigmentation of the skin, patchy scaling, itching, alopentsiya, dermatitis, hand-foot syndrome.
Admission Tutabina, reviews may lead to an increase in body temperature, enhanced tearing, swelling of the lower limbs, anemia, pain in the limbs and waist.
Storage and supply of pharmacies
The tablets are dispensed from the pharmacy Tutabin only by prescription. They should be stored at room temperature in a dry and dark place, away from children and pets.