Capoten

 Capoten

Capoten - synthetic drug, an angiotensin-converting enzyme.

It is used for hypertension, diabetic nephropathy and heart failure.

Product form

Capoten produced in the form of white square biconvex tablets. Each tablet contains 25 mg of active substance - captopril. Other ingredients - corn starch, microcrystalline cellulose, lactose and stearic acid. 10 and 14 units in blister packs, 2 and 4 in the blister pack.

Pharmacological action

The active substance of the hood reduces blood pressure without causing tachycardia and decreases myocardial oxygen demand.

The maximum effect is usually an hour. The optimal value is achieved with long-term use the hood in a few weeks.

Capoten is indicated for use in patients with diabetic nephropathy, slowing down the development of renal disease in diabetes.

Indications Capote

Capoten is indicated for use in:

  • Diabetic nephropathy in type 1 diabetes;
  • Hypertension, including renovascular;
  • After a myocardial infarction in a stable state (left ventricular dysfunction).

Capoten is also shown in a combination therapy for the treatment of chronic heart failure.

Contraindications

Capoten is contraindicated in the instructions for:

  • Hyperkalemia;
  • Aortic stenosis and similar obstructive changes that hamper the outflow of blood from the left ventricle;
  • Condition after kidney transplantation;
  • Angioedema;
  • Severe disorders of the liver and kidneys;
  • Hypersensitivity to the drug or to other ACE inhibitors;
  • Bilateral renal artery stenosis or stenosis of the artery to a solitary kidney with progressive azotemia.

Capoten is contraindicated during pregnancy and lactation.

The drug is not used in pediatrics and is not indicated for children under 18 years of age due to lack of the necessary clinical trials.

According to the instructions Capoten prescribed with caution in:

  • Vomiting or diarrhea;
  • Cerebral ischemia and ischemic heart disease;
  • Diabetes mellitus - due to the increased risk of hyperkalemia;
  • Primary hyperaldosteronism,
  • Severe autoimmune connective tissue diseases;
  • Suppression of bone marrow hematopoiesis because of possible risk of neutropenia and agranulocytosis;
  • Compliance malosolevoy or salt-free diet;
  • Elderly patients.

Guide to the use of the hood

 Capoten Tablets

Capoten tablets taken one hour before a meal. The dosage depends on the disease and set individually.

Capoten is used for hypertension:

  • The initial dose of hypertension lowest - 12, 5 mg twice a day. Until the optimum effect of the dose should be gradually increased at intervals of several weeks to months;
  • The average therapeutic dose for moderate and mild arterial hypertension is - 2 tablets of the hood 2 times a day; the maximum dose - twice;
  • In severe hypertension initial minimum dose 12 5 mg 2 times a day and increased gradually brought to a maximum daily dose - 2 tablets three times a day.

According to the instructions Capoten in chronic heart failure is prescribed in cases of ineffective use of diuretics. The initial dose in this case - on the 6, 25 mg three times a day. Supportive - 25 mg 2-3 times a day with a maximum -6 tablets per day. The dose is increased no more frequently than every two weeks.

Use of the hood in a stable condition after suffering a heart attack can begin three days 6, 25 mg per day. Depending on the tolerability of the drug dose can be increased gradually to the maximum.

The daily dose for diabetic nephropathy - 3 to 4 tablets of the hood, which is divided into 2-3 receptions. 2 tablets twice daily administered with insulin-dependent diabetes mellitus.

In moderate and mild renal dysfunction Capoten is used for 75-100 mg, with heavy - 2 tablets a day. The dose can be gradually increased until the desired therapeutic effect.

With proper selection of doses, the hood of reviews is usually well tolerated.

In case of overdose there may be a sharp drop in blood pressure.

Side effects

When using the hood may develop:

  • Peripheral edema, orthostatic hypotension and tachycardia;
  • Bronchospasm or pulmonary edema. If you cancel the hood of reviews may develop a dry cough;
  • Angioedema of the mucous membranes, feet, lips and face, tongue, throat or larynx, and the drug should be discontinued and implement a thorough medical supervision;
  • Drowsiness, headache, ataxia, paresthesia, visual disturbances, dizziness;
  • Agranulocytosis, neutropenia, thrombocytopenia, and anemia.

In the opinion of Capoten may cause taste disturbance, stomatitis, abdominal pain, dry mouth, diarrhea, gingival hyperplasia, hepatitis.

During treatment Kapotenom need to monitor renal function and the number of white blood cells.

While the use of diuretics and vasodilators Capote antihypertensive effect is enhanced, and when combined with indomethacin or other nonsteroidal anti-inflammatory drugs - decreased.

Avoid the simultaneous use of the hood with a potassium-sparing diuretics and potassium supplements. The simultaneous use of the hood with immunosuppressants increases the risk of various hematological disorders.

Capoten is contraindicated during pregnancy and lactation.

Storage conditions

Capoten is related to the list B and prescription. Shelf life - 5 years.





Яндекс.Метрика