Symbicort

Symbicort - pharmacological drug used for the treatment of obstructive pulmonary diseases.

Trade name Symbicort Turbuhaler

Structure and Composition

According to the instructions Symbicort is available in powder form for inhalation dose. Active ingredients - budesonide, formoterol fumaratdigidrat. Also, as an auxiliary substance in the drug includes lactose monohydrate.

 Symbicort in a cardboard bundle

Produced drug inhalers rotating dosing for 60 or 120 doses. The inhaler mouthpiece is rotatable.

The contents of the inhaler are white granules and rounded shape.

In the 1st dose of Symbicort may contain: budesonide 80 or 160 micrograms of formoterol fumaratdigidrata 4, 5 micrograms.

The pharmacological action of Symbicort

According to the instructions Symbicort is a combination of corticosteroids and selective beta 2 adrenomimetic. Active substances exhibit different mechanisms of action and enable the use of the preparation as cupping, and for maintenance treatment of asthma.

Budesonide is an inhaled glucocorticoid and anti-inflammatory action. It reduces the severity of symptoms and reduce the frequency of exacerbations of asthma. Thus it has side effects is much lower than with systemic glucocorticoids. As a result of budesonide decreases bronchial walls edema, mucus production and airway hyperresponsiveness.

Formoterol is a selective antagonist of the b2-adrenergic receptors and induce relaxation of airway smooth muscle. Bronchodilator effect occurs within 1-3 minutes after inhalation and lasts up to 12 hours. The combination of formoterol and budesonide reduces the severity of asthma symptoms, improve the functional state of the bronchi and reduces the frequency of relapses.

According to reviews Symbicort was well tolerated by patients, including children's age (6 years).

In patients with chronic obstructive pulmonary disease with severe respiratory failure during treatment with Symbicort showed significant improvement.

Indications

According to the instructions Symbicort is indicated for treatment of the following conditions:

  • bronchial asthma;
  • chronic obstructive pulmonary disease (for patients with a severe form).

Contraindications to the use of Symbicort

According to the instructions Symbicort is contraindicated in case of hypersensitivity to the ingredients, as well as children up to 6 years.

Precautions Symbicort should be used in pulmonary tuberculosis, fungal, viral or bacterial respiratory tract infections, hyperthyroidism, diabetes, pheochromocytoma, severe hypertension, aneurysm of any location, severe heart failure, tachyarrhythmia.

Use during pregnancy and lactation

There has been no adequate clinical studies on the use of Symbicort during pregnancy. This drug should be used only in cases where the potential benefits significantly outweigh the risks to the fetus.

At the present time it is not known whether the components of Symbicort penetrate into breast milk. Therefore it is not recommended to use the drug while breastfeeding.

Dosage and administration of Symbicort

According to the instructions Symbicort is not recommended for the treatment of bronchial asthma lung flow. Selection of dose is carried out individually depending on the severity of the disease.

Children older than 6 years of Symbicort Turbuhaler is recommended at a dose of 80/4, 5 g of 2 inhalations 1-2 times a day.

Children between the ages of 12-17 years old adults similar dose Symbicort (1-2 inhalation dose 80/4, 160/4, or 5 mg, 5 mg, 2 times a day).

Adults Symbicort Turbuhaler recommended dose of 80/4, 160/4 or 5 g, 5 g of 2 inhalations 1-2 times a day. In case of need may increase the dose to 4 inhalations per day. Upon reaching the optimal control of asthma symptoms in patients receiving Symbicort, may reduce the dose to the lowest effective. Review Symbicort effectively helps to prevent asthma attacks, and easy to use.

Patients treated with this drug, you should regularly consult a doctor to control the optimal dose.

Patients with chronic obstructive pulmonary disease is usually assigned to 2 inhalations Symbicort 160/4 Turbuhaler, 5 mg twice a day.

side effect

Review Symbicort rarely causes side effects. The most common adverse reactions are: tremor, headache and palpitations. These symptoms are usually mild and self-expressed resolve within a few days after initiation of therapy. Also, reviews, Symbicort in rare cases can cause candidiasis of the oral mucosa and throat, hoarseness, cough. Very rarely Symbicort, reviews causes agitation, anxiety, sleep disorders, bruising, allergic reactions, heart rhythm disorder.

The use of this drug may result in an increased concentration of insulin in the blood, which should be considered in patients with diabetes.

Overdose Symbicort

Symptoms of overdose of formoterol are: tremor, palpitations, headache, nausea, vomiting, arrhythmia. In case of overdose of budesonide clinically significant responses were noted. Treatment is symptomatic.

 Symbicort inhaler with a rotating dispenser

In chronic higher doses of Symbicort may cause systemic effects of glucocorticoids (adrenal suppression, hypercortisolism).

Interaction with other drugs

Avoid the combination of Symbicort and ketoconazole.

Do not appoint simultaneously Symbicort and beta - blockers (even as eye drops).

Concomitant use with quinidine, procainamide, phenothiazines, antihistamines, MAO inhibitors, tricyclic antidepressants can cause ventricular arrhythmias.

Symbicort Interactions with other drugs used in the treatment of asthma, it is noted.

Specific instructions for use of Symbicort

According to the instructions Symbicort should be lifted gradually, not abruptly stop treatment recommended.

This product is not intended for initial treatment of bronchial asthma.

Patients need to know that the use of Symbicort should be regular, even in the absence of symptoms. Do not start treatment with this drug in acute asthma.

Review Symbicort in rare cases may cause paradoxical bronchospasm after inhalation. If you experience this complication is necessary to cancel the drug and to choose an alternative treatment.

In patients with diabetes mellitus during use Symbicort should monitor blood glucose.





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