Sulfadimidine - antibacterial sulfa drug.
The composition and the form of sulfadimezin
Sulfadimezin produce as white ploskotsilindricheskoy form tablets. One tablet contains active substance - sulfadimidine 0 5 g
Auxiliary components: potato starch, stearic acid, talc, polysorbate 80.
In packs of 10 tablets.
Bacteriostatic antimicrobial sulfonamides. The mechanism of action is due to inhibition of sulfadimezin digidropteroatsintazy, competitive antagonism with para-aminobenzoic acid, a violation of the synthesis of tetrahydrofolic acid required for the synthesis of pyrimidine and purine.
According to the instructions, Sulfadimidine active against gram-negative and gram-positive cocci, Clostridium perfringens, Escherichia coli, Vibrio cholerae, Corynebacterium diphtheriae, Chlamydia spp., Shigella spp., Bacillus anthracis, Actinomyces israelii, Yersinia pestis, Klebsiella spp.
Sulfadimidine - indications for use
According to the instructions, the indication to sulfadimezin are diseases caused by susceptible to the microorganism:
- otitis media;
- exacerbation of chronic bronchitis;
- inflammatory diseases of the urinary tract;
- wound infection;
- inflammatory diseases of the biliary tract.
The instructions to sulfadimezin contain the following contraindications:
- medullary hematopoiesis depression;
- congenital lack of glucose-6-phosphate dehydrogenase;
- Children under three years of age;
- pregnancy and breastfeeding;
- chronic renal failure;
- hyperbilirubinemia in children;
- hypersensitivity to one or more of the ingredients.
Be wary appoint Sulfadimidine according to the instructions in the following cases:
- allergic diseases;
- abnormal liver function.
Dosing and dosing regimen sulfadimezin
According to the instructions, Sulfadimidine taken orally. The dosage regimen depends on the indication for sulfadimezin.
If tonsillitis, otitis media children older than three years, tend to take on 0, 05-0, 075 g per kg of body weight, divided into several stages, adults - 1 g twice a day. Duration - one week.
When shigellosis is necessary to two courses of therapy. The first course: 1 g formulation every four hours during the first and second day of treatment and then, to the third and fourth day - 1 g every six hours for the fifth and sixth day - 1 g every eight hours.
When sinusitis, exacerbation of chronic bronchitis, erysipelas children take on 0, 1-0, 15 g per kg of body weight per day. Adults appoint Sulfadimidine by indications in a dosage of 1 g per day. Duration - 1-1, 5 weeks.
Pneumonia and wound infections dosage for children is 0, 1 g per kg of body weight for the first time, then the dose was increased to 0, 1-0, 15 g per kg of body weight per day. Adults take 2 grams for the first time, then the dosage was increased to 1 g per day. After two or three days after the symptoms disappear welcome sulfadimezin stopped.
In inflammatory diseases of the urinary and biliary tracts dosage for children is at 0, 05-0, 075 g per kg of body weight per day. Adults are Sulfadimezin for instructions 0 and 5 g per day. The duration of the drug is 1-1, 5 weeks.
The second course was conducted five days after the first course. In the first and second day of taking 1 g every four hours and eight hours at night. On the third and fourth day - 1 g every four hours at night do not take the drug. On the fifth day of the drug is 3 g per day.
The maximum single dosage for adult is 2 g daily - 7 g Children maximum daily dosage of 0, 1-0, 15 g per kg of body weight.
Side effects sulfadimezin
According to reviews, Sulfadimidine may cause the following side effects of the various systems of the body's vital functions:
- allergic reactions;
Drug interaction sulfadimezin
Concomitant use sulfadimezin:
- with bactericidal antibiotics decreases their efficiency;
- with Thiamazolum, chloramphenicol increases their hepatotoxicity;
- procaine and benzocaine to reduce their antimicrobial activity;
- with methenamine and ascorbic acid increases the risk of crystalluria;
- with antacids reduces absorption of the drug in the intestine;
- with hypoglycemic agents, NSAIDs, coumarin anticoagulants, phenytoin increases the severity of side effects of the drug.
The drug Sulfadimidine stored in a dry, dark, cool place for no longer than five years.