Sodium nitrite

Pharmacological action

 Sodium nitrite
 Sodium nitrite was prepared by the reaction of sodium compounds and nitrite ions in the aqueous medium.

The material was used in medicine as a vasodilator and an antidote for poisoning hydrocyanic acid (cyanide), it also used as a preservative in the food industry.

The tool reduces the flow of blood to the right atrium, extends the peripheral veins, reduces peripheral vascular resistance. Furthermore, the use of sodium nitrite provides an opportunity to reduce myocardial oxygen demand, improve coronary blood flow.

The therapeutic effect of the agent like amyl nitrite, but it is longer.

Product form

Release means in the form of a solution 0% 5-2.

Indications for use of sodium nitrite

The use of sodium nitrite is indicated for angina spasm of cerebral arteries intoxication salts of hydrocyanic acid.

Contraindications

Means you can not take a person in a state of collapse, shock, when arterial hypotension (if the pressure is lower than 100/60), acute myocardial, toxic pulmonary edema, hemorrhagic stroke, intracranial hypertension, angle-closure glaucoma.

 Take a solution of sodium nitrite inside or intravenously
 Instructions for use of sodium nitrite

Sodium nitrite to treat angina, relieve spasms of cerebral vessels taking inside after eating 2-3r / day 100-200ml 0, 5% solution. Permitted dosage for adults: single - 300mg daily - 1g.

When cyanide poisoning 1-2% solution is administered intravenously: 10-20ml.

side effects

It is noted that the injury can cause sodium nitrite in the uncontrolled use it inside - there are gastrointestinal disorders in the form of diarrhea, abdominal pain, vomiting, nausea. Action agents on the vascular system may be accompanied by headaches, facial flushing, dizziness, reduced pressure, increased heart rate.

Harm sodium nitrite is also evident in the use of it in high doses: can develop collapse, fainting, palpitations, blurred vision, sweating, intestinal colic, melena, bradycardia, dyspnea, intracranial hypertension, hyperpnoea, AV block, paralysis, coma. In order to eliminate the symptoms of an overdose the stomach should be washed. If you start methemoglobinemia (a type of hypoxia), you must provoke vomiting and introduce intravenous 1% solution of methylene blue - 1-2mg / kg of body weight and be sure to seek medical help.

Lethal dose for human - 2-6gr substance.





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