Sibazon

Sibazon - antianxiety drug.  Sibazon in solution

Structure and Composition sibazon

The drug is available in the following dosage forms:

  • tablets for 0, 005 g, 20 pieces in a package;
  • Tablets Sibazon children coated to 0, 001 and 0 002 g in a package of 20 pieces;
  • solution was 0, 5% of 2 ml vials of 10 vials of the pack.

The active substance sibazon - diazepam.

Pharmacological action

Tranquilizer. According to the instructions Sibazon a calming effect on the central nervous system, reducing feelings of fear, anxiety and tension.

The drug has a pronounced anticonvulsant and antiarrhythmic effect, reduces muscle tone, reduce the secretion of gastric juice.

In addition, Sibazon Review has soporific effect, potentiates the effect of neuroleptic drugs and alcohol.

Indications sibazon

According to the instructions Sibazon shown in the following cases:

  • anxiety, insomnia;
  • alcohol withdrawal syndrome (agitation, tension, tremor, anxiety, transient reactive states);
  • spasm of skeletal muscles at the local trauma;
  • spastic condition caused by spinal cord or brain (tetanus, athetosis, cerebral palsy);
  • progressive chronic polyarthritis, rheumatoid pelvispondiloartrite, bursitis, myositis, arthritis;
  • arthrosis, accompanied by a voltage of skeletal muscles;

In the combined therapy according to the instructions Sibazon prescribed for:

  • dysphoria;
  • hypertension;
  • ulcer 12 duodenal ulcer and stomach;
  • psychosomatic disorders in gynecology and obstetrics (preeclampsia, menstrual and menopausal disorders);
  • status epilepticus;
  • eczema and other diseases accompanied by increased irritability and itching.

Apply Sibazon premature labor (only at the end of the third trimester of pregnancy), and detachment of the placenta, and to facilitate labor.

Contraindications Sibazon

According to the instructions Sibazon contraindicated in the following cases:

  • hypersensitivity to diazepam;
  • shock, coma;
  • acute alcohol intoxication, accompanied by the weakening of vital functions;
  • acute intoxication of drugs that cause central nervous system depression, including hypnotics and narcotic analgesics;
  • myasthenia gravis, angle-closure glaucoma;
  • Pregnancy, especially the first trimester;
  • lactation;
  • severe COPD, acute respiratory distress syndrome, Lennox-Gastaut syndrome, or absence.

Sibazon contraindicated in children younger than 6 months (to the inside), and up to 1 month (after intravenous and intramuscular administration).

In the opinion of Sibazon should be used with caution in:

  • epilepsy and seizures, as in the beginning of treatment with diazepam or in case of abrupt withdrawal may accelerate the development of seizures or status epilepticus;
  • kidney or liver failure;
  • spinal and cerebral ataxia;
  • the propensity to abuse drugs;
  • giperkinezah;
  • organic brain diseases;
  • sleep apnea;
  • hypoproteinemia.

Caution should be used Sibazon in old age.

Side effects sibazon

According to reviews Sibazon may cause the following side effects:

  • Nervous system: dizziness, drowsiness, fatigue, disorientation, poor concentration, ataxia, lethargy, poor coordination, depression, tremors, headache, confusion, catalepsy, euphoria, extrapyramidal dystonic reactions.
  • Hemopoietic system: neutropenia, leukopenia, thrombocytopenia, agranulocytosis, anemia.
  • The digestive system: heartburn, nausea, vomiting, constipation, loss of appetite, hiccups, hypersalivation, elevated liver enzymes, abnormal liver function, jaundice.
  • Urogenital: delay or urinary incontinence, dysmenorrhea, decreased or increased libido, impaired renal function.
  • Cardiovascular system: decrease in blood pressure, tachycardia, palpitations.
  • Allergic reactions: itching, skin rash.
  • Effect on the fetus: CNS depression, teratogenicity (especially in the first trimester). In the case of the mother sibazon can be observed suppression of sucking reflex, and respiratory failure in children.
  • Local reactions: local thrombosis or phlebitis at the injection site.
  • Other side effects: drug dependence and addiction, bulimia, blurred vision, weight loss, depression of the respiratory center.

With a sharp lifting Sibazon Review can cause a syndrome "cancel" (anxiety, nervousness, irritability, sleep disorders, anxiety, depression, nausea, tremors, vomiting, hallucinations, convulsions, increased sweating, smooth muscle spasm).

In the case of obstetrics Sibazon Review can cause in term or preterm infants dyspnea, hypothermia, muscular hypotension.

Dosing and dosing regimen sibazon

According to the instructions Sibazon used intramuscularly, intravenously, orally and rectally.

Dosage is calculated individually in dependence on the sensitivity to the drug, the condition of the patient and the clinical picture of the disease.  Sibazon as tablets

Typically, as anxiolytic drug prescribed orally in a dosage of 2, 5-10 mg two to four times per day.

In psychiatry and neurology at the instructions Sibazon appoint 5-10 mg up to three times a day.

When hypertension and angina, as well as when used in obstetrics and gynecology (psychosomatic disorders) Sibazon Review effective dosage of 2-5 mg up to three times a day.

Babies Sibazon prescribed for psychosomatic disorders and spastic conditions. As a rule, children Sibazon prescribe low dose and gradually increase it to the optimum.

The maximum daily dosage sibazona children 6 months of 1-2 5 mg or 40-200 mg per kg body weight.

Storage conditions

Keep it in a dry, dark place. Shelf-life solution for injection - 24 months, tablet 0 005 g - 36 months, tablets Sibazon children of 0, 001 and 0, 002 g - 24 months.





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