Sevoran - pharmacological agents from the group of inhaled obscheanesteziruyuschih funds.
Structure and Composition
According to the instructions it Sevoran issued in the form of liquid for inhalation. The active ingredient - sevoflurane. Externally, the product is a clear liquid with no color. In accordance with the requirements of medicines for anesthesia Sevoran not ignite or explode. Any additives and stabilizers, the preparation does not contain. Sevoran easily mixed with ether, ethanol, benzene and chloroform, and very poorly soluble in water.
Sevoran produced in bottles of 100 and 250 ml. Bottles made of amber glass or plastic. The carton 1 or 6 vials of medication along with instructions.
Pharmacological action Sevoran
According to the instructions Sevoran has obscheanesteziruyuschim action. The use of this drug as an inhalation induction of anesthesia causes rapid loss of consciousness. After the cessation of anesthesia and consciousness recovers quickly.
Induction with Sevoran, reviews, accompanied by minimal signs of arousal and does not cause an increased production of mucus in the tracheobronchial tree. Active drug (as for other means of anesthesia inhalation) causes a dose-dependent inhibition of the respiratory function and reduce blood pressure.
According to the instructions Sevoran weakly acts on intracranial pressure and does not reduce the response to carbon dioxide (CO
). The drug does not interfere with the function of the liver or kidneys, and does not lead to an increase in the phenomenon of hepatic / renal failure.
Sevoran rapidly cleared from the lungs. Finally pathway of the drug is not set.
According to the instructions Sevoran indicated for the opening and maintenance of anesthesia during surgery, in both children and adults. The drug can be used in the outpatient setting and in the hospital.
- hypersensitivity to sevoflurane or other halogenated compounds;
- genetic susceptibility to the development of malignant hyperthermia (even if suspected).
Precautions Sevoran should be used in patients with impaired renal function, as finally established its safety in this group of patients.
When neurosurgical operations Sevoran should be used with caution if the patient there is a risk of increased intracranial pressure (in combination with measures aimed at lowering intracranial pressure).
Use during pregnancy and lactation
In clinical studies on animals Sevoran had no teratogenic effects. However, significant studies in pregnant women have not been conducted, therefore, this drug should be used only if absolutely indicated.
The clinical study on the use of Sevoran anesthesia for caesarean section showed its safety, both for the mother and for the newborn.
According to the instructions Sevoran no information on its release in breast milk. Therefore, during lactation is possible to use this drug with caution.
Dosing and Administration Sevoran
Medicines for premedication should be selected individually anesthesiologist.
For anesthesia should be used evaporator, which is specially calibrated for Sevoran.
Doses are selected individually (the age and condition of the patient), and titrate to the desired effect. After inhalation Sevoran (mask) can be administered short-acting barbiturate or other intravenous induction agent for general anesthesia. According Sevoran instructions can be used in oxygen or a mixture of nitrous oxide and oxygen.
According to responses Sevoran inhalation at concentrations up to 8% provides an introduction to general anesthesia in adults and children over 2 minutes.
For maintenance of general anesthesia Sevoran must be maintained at a concentration of 0, 5-3% (possibly in combination with nitric oxide).
It should be noted that with age, the patient's need for Sevorane for administration of anesthesia decreases. And 80-year-old man usually requires ½ dose (from that of the patient's young age).
In the opinion of Sevoran provides a quick exit from the general anesthesia. Note that in this context may require postoperative analgesia at an earlier date.
In the opinion of Sevoran rarely causes side effects. As with all the means for inhalation anesthesia, the drug can cause suppression of breathing and heart (dose-dependent). Usually adverse reactions are transient and mild / moderate.
The main adverse reactions when used Sevoran: nausea, vomiting, decreased / increased blood pressure, increased cough, excessive salivation, excitation, chills, tachycardia / bradycardia, dizziness, breathing disorders (sleep apnea, laryngospasm), pyrexia.
Sevoran, reviews, rarely causes postoperative hepatitis (exact relationship with the drug has not been established), convulsions and allergic reactions (rash, urticaria, bronchospasm, anaphylactic reactions).
In the event of an overdose of the drug should be discontinued inhalation and start ventilation (or a controlled subsidiary) with the introduction of oxygen, and maintain cardio - vascular activity.
Interaction with other drugs
According to the instructions it Sevoran well combined with drugs that are commonly used in surgical practice (including by means of affecting the function of the nervous system, muscle relaxants, anti-bacterial agents, hormones, blood products). Adverse interactions have been identified.
Special instructions for use Sevoran
According to the instructions Sevoran may be used only anesthesiologist with experience in general anesthesia. If you use this drug for general anesthesia must have all proper equipment (ventilator for airway management, resuscitation).
To submit Sevoran need specially calibrated vaporizers.
It should inform the patient that after general anesthesia for some time should not drive vehicles and work with moving mechanisms have been a focus may be compromised.