Seroquel - an antipsychotic drug used for the treatment of chronic and acute psychosis.
Seroquel belongs to the antipsychotic drugs - neuroleptics.
The active ingredient of the drug as compared to dopamine D1- and D2-receptors in the brain shows a higher affinity for serotonin 5HT2-receptors.
Standard tests showed Seroquel antipsychotic activity, and in clinical trials has shown efficacy in the treatment of positive and negative symptoms of schizophrenia.
Seroquel tablets contain 25 mg (engraved with «SEROQUEL 25"), 100 mg (engraved with «SEROQUEL 100") and 200 mg (engraved with «SEROQUEL 200") of the active substance - Quetiapine fumarate.
Other ingredients - calcium phosphate, magnesium stearate, microcrystalline cellulose, povidone, lactose monohydrate and sodium carboxymethyl.
10 pieces in a blister.
Analogs of Seroquel
By analogues of the active substance quetiapine include drugs Viktoel, Kventiaks, Gedonin, Lakvel, Ketiap, Kutipin, quetiapine and Nantarid.
According to the mechanism of action of quetiapine closest analogues are medicines Azaleptin, Zalasta, Zyprexa, olanzapine, Azaleprol, Safris, Normiton, Olaneks, Klozasten, Zalasta Ku tab and Parnasan.
Indications for use of Seroquel
According to the instructions Seroquel is prescribed for the treatment of:
- Depressive episodes of moderate to severe severity in the structure of bipolar disorder (treatment usually long);
- Manic episodes of bipolar disorder in the structure;
- Chronic and acute psychosis, including schizophrenia.
Seroquel is contraindicated in case of hypersensitivity to apply to quetiapine or excipients of the drug and at the same time:
- Azole antifungals;
- Protease inhibitors;
With care prescribe Seroquel for instructions:
- Cardiovascular and cerebrovascular diseases, and other conditions that are conducive to hypotension;
- With a history of seizures;
- In old age;
- When liver failure.
Dosing of quetiapine
Seroquel for instructions take twice a day.
For the treatment of chronic and acute psychoses including schizophrenia, taken on the first day 50 mg, in the next three days the dose is increased to 100 mg, 200 mg and 300 mg, respectively. Subsequently, the daily dose of quetiapine varies from 150 mg to 750 mg (maximum).
As monotherapy or as an adjuvant therapy for the treatment of mood stabilization manic episodes in bipolar disorder Seroquel structure employed in the first four days, 100 mg, 200 mg, 300 mg and 400 mg, respectively. Generally, an effective dose of 400-800 mg per day.
Quetiapine instructions for the treatment of depressive episodes of bipolar disorder in the structure is prescribed once daily at a dose - 300 mg, maximum - 600 mg.
Abolition of Seroquel and analogues of the drug is recommended with caution, to avoid insomnia, nausea and vomiting, and exacerbation of psychotic symptoms and the emergence of involuntary movement disorders such as akathisia, dyskinesia and dystonia.
People in old age, as well as kidney and liver failure treated with quetiapine is recommended to start with 25 mg per day and gradually increase the dose to be effective.
The main symptoms of Seroquel overdose include:
- Lowering blood pressure;
Use caution when applying Seroquel at the same time:
- Azole antifungals;
- Macrolide antibiotics;
- Drugs, central nervous system depressants;
- Drugs containing ethanol.
Use Seroquel during pregnancy is allowed only for reasons and under medical supervision. Breast-feeding while taking Seroquel is recommended to interrupt.
Side effects of Seroquel
The most common causes of Seroquel Review heartbeat, increased blood pressure, sore throat, dysarthria, anorexia, cough, and increased sweating.
Furthermore, according to reviews Seroquel may impair the central nervous system, most often manifested as drowsiness, impairment of consciousness, dizziness, muscle rigidity.
Long-term use of Seroquel increases the risk of tardive dyskinesia, which may require dosage reduction or complete abolition of the drug.
The most common digestive disorders with quetiapine for reviews include constipation, dry mouth, and dyspepsia.
Among the possible allergic reactions most likely to develop eosinophilia and angioedema.
Also, the use of Seroquel can cause reviews:
- Orthostatic hypotension (accompanied by dizziness);
- Peripheral edema;
- Mild asthenia.
Seroquel belongs to a number of antipsychotic drugs that are dispensed by prescription. It should not be stored longer than 36 months pills.