Sandimmun

Sandimmun - immunosuppressive agent for organ transplant.

Pharmacological action

 Sandimmun capsule

Sandimmun is a polypeptide consisting of 11 amino acids, exerts an immunosuppressive effect.

Active substance Sandimmun - cyclosporine, which increases the lifetime of transplants of kidney, heart, pancreas, skin, lung, small intestine, bone marrow, and prevents the development of transplantation of dermal hypersensitivity, diseases "graft versus host" and arthritis.

Product form

Sandimmun manufactured as capsules, solutions for infusion and oral administration.

Indications

Sandimmun on instructions given to patients after a heart transplantation, pancreas, liver, bone marrow, kidney, lung, heart-lung transplant - to prevent rejection of the transplanted organ.

There are good reviews about Sandimmun, used for graft rejection by patients who are already taking other immunosuppressants and disease, "graft versus host".

The drug can be used to treat autoimmune diseases, uveitis, Behcet's disease, endogenous uveitis, nephrotic syndrome, psoriasis, rheumatoid arthritis.

Instructions Sandimmun: how to use

When a bone marrow transplant the day before surgery is administered by intravenous drip of 2-6 mg of Sandimmun per kg patient. Inject the drug intravenously continued for two weeks after the transplant, after which the patient is transferred to the tablet.

When transplanting internal vital organs administered once Sandimmun for 4-12 hours before surgery - 3-5 mg / kg. 1-2 weeks after transplanting the drug is administered at the same dose every day, then the dosage is lowered is adjusted to a maintenance - 0 7-2 mg / kg.

For children, the dosage of Sandimmun after as calculated by weight. Input data are the same as used for adults.

Capsules adult prescribe a dosage of 10-15 mg / kg, taking them 12 hours prior to organ transplantation. Over the one to two weeks after surgery take capsule at the same dose and then gradually by 5% per week to reduce the dosage level of 2-6 mg / kg.

If you plan to bone marrow transplantation, on the day before surgery and again 2 weeks later taking 12 capsules per dose, 5-15 mg / kg.

Supportive therapy lasts a year after the transplant. There are reviews of Sandimmun by taking his patients, indicating that even after this time, after the end of treatment there may be a rejection reaction. In this case, it is recommended to resume receiving Sandimmun.

For treatment of endogenous uveitis receive 5 mg / kg per day to as reduced inflammation and restored visual acuity.

Nephrotic syndrome children are given 6 mg / kg, for adults - 5 mg / kg.

In rheumatoid arthritis, the first 6 weeks of Sandimmun take 3 mg per kilogram body weight per day. If necessary, the normal amount of the drug is increased portability.

In psoriasis advised to take 2 to 5 mg / kg per day.

 Sandimmun - solution for infusion

Side effects Sandimmun

Sandimmun may provoke the development of malignant skin diseases and lymphomas, anaphylactic reaction, increasing the pressure, gingival hyperplasia, nephropathy, hypertrichosis, appetite loss, hyperkalemia, nausea, diarrhea, pancreatitis, abdominal pain, hypomagnesemia, muscle spasms, headache, blurred vision, anemia, dysmenorrhea, weight gain, tremors, swelling.

There are reviews of Sandimmun, causing a burning sensation in the feet and hands, renal failure, impaired motor activity.

With an overdose of Sandimmun may occur malfunction of the kidneys. The patient in this case is usually carried out symptomatically. Hemoperfusion and hemodialysis considered ineffective.

The instructions Sandimmun indicated that patients who experienced higher pressure hypercreatininemia, reduce medication dosage by 25-50%.

Contraindications

Sandimmun should not be taken in the presence of malignancy in the precancerous skin diseases, hypersensitivity during breastfeeding, pregnancy.

Babies under one year do not prescribe medication.

Precautions should be taken Sandimmun varicella and other diseases of viral origin, with hyperkalemia, infection, hepatic / renal failure, hypertension, malabsorption syndrome.





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