Roferon

 Roferon solution

Roferon - an antiviral drug.

Pharmacological action

The structure includes Roferon interferon alfa-2a, which is getting into the body, stimulates immune response to viral infections: neutralizes viruses, or removes them affected cells.

Roferon also possesses anti-tumor properties, but the mechanism of this action is not known until the end. It is only stated that in tumor cells which have been treated Roferon decreases production process of protein, RNA and DNA, and thus inhibits proliferation of preparation of tumor cells.

Product form

Produce a solution for subcutaneous injection and spark Roferon.

Indications

Roferon prescribed for multiple myeloma, Ph-positive chronic myeloid leukemia, hairy cell leukemia, cutaneous T-cell lymphoma, thrombocytosis, myeloproliferative diseases appear when the character, with non-Hodgkin lymphoma with a low degree of malignancy.

Good effect is observed when using Roferon for treating metastatic malignant melanoma, renal cell carcinoma, Kaposi sarcoma in AIDS patients, melanoma after its removal (if not damaged lymph nodes and metastases).

In addition, Roferon according to the instructions, you can assign an active chronic hepatitis B and C and to remove genital warts.

Roferon Guide: how to use

For these indications the drug is administered subcutaneously. Candles Roferon rarely used, at the discretion of the physician.

For the treatment of multiple myeloma drug prescribed at a dose of 9 million IU per week (in three stages). Gradually, during treatment every week dosage increased until 9-18 million IU. Treatment for multiple myeloma is usually long.

Patients with hairy cell leukemia Roferon first appointed at a dose of 3 million IU. Injections are doing every day for 16-24 weeks. If the patient has an intolerance, the dosage was reduced to 1, 5 million IU, or reduce the number of injections - up to three times a week.

For the treatment of T-cell lymphoma patients after 18 years, to appoint 3 million IU Roferon and gradually, within three months, the dosage was adjusted to 18 million IU.

To maintain the effect of therapy the patient inject the drug three times a week - 18 million IU.

Treatment of chronic myeloid leukemia Roferon lasts 8-12 weeks. First administered 3 million IU gradually and within 84 days, adjusted to 9 million IU per day. The indicated dosage is designed for patients over 18 liters. Question the possibility of appointing the drug to young children has not been studied.

For the treatment of thrombocytosis Roferon instructions prescribed by taking 3 million IU each day. Within a month, the dosage is adjusted to 6 million IU. In order to maintain the therapeutic effect of supportive therapy: inject 1-3 million IU once a week.

For the treatment of non-Hodgkin's lymphoma Roferon taken after chemotherapy (through 1-1, 5 months) - 3 million IU three times a week for a year.

Patients suffering from AIDS and Kaposi's sarcoma, which is detected, taking the drug at a dose of 3 million IU daily for 10-12 weeks. Gradually possible dosage is increased up to 36 million IU. Treatment Roferon can give results only if the patient is not suffering from opportunistic infections before, and it does not have high temperature (over 38 ° C), not reduced weight, no night sweats. In addition, the initial amount of T4 lymphocytes should be greater than 200 microliters. Effect of treatment in most cases occurs only after three months. Continue to take Roferon be before the tumor will disappear. The maximum duration of therapy - 20 months.

In renal cell carcinoma in patients with metastatic or recurrent tumor, immediately appoint 36 million IU Roferon per day. The treatment lasts for 8-12 weeks (no more than 16 weeks). If a long time treatment effect is not observed, the drug is stopped.

Practice and complex therapy carcinoma: Roferon appointed simultaneously with vinblastine, but in this case, treatment is initiated with a dose of 9 million IU per week. From the second week of therapy take 18 million IU per week (in three stages). Then move on to 54 million IU per week. If the observed intolerance may be reduced dosage Roferon to 18 million IU per week. Vinblastine is administered intravenously at a dosage of 100 mg / kg body weight every three weeks.

When metastatic melanoma Roferon prescribed at a dose of 54 million IU. Injection was carried out for 12 weeks.

After surgical removal of the melanoma enter Roferon begin no later than 1, 5 months after surgery. The therapeutic dosage - 9 million IU per week. The treatment lasts for 1, 5 years.

For the treatment of chronic hepatitis B taking the drug at a dose of 13, 5-27 million IU per week for 4-6 months. If 3 or 4 months would not improve the treatment Roferon stopped.

The instructions Roferon indicated that hepatitis C it is better taken with ribavirin. If the patient had not been treated, it is assigned 9 million IU Roferon a week for six months.

If the disease recurs, designate 13, 5 million IU per week for six months. In chronic hepatitis B treatment may be carried out within 6-12 months.

For the treatment of genital warts injected with Roferon three times a week for 1-2 months. Permissible dosage - 1-3 million IU. In this indication, if the warts appear on the cervix may designate candles Roferon. The dosage and frequency of application is determined by the doctor.

side effects

After injection Roferon patient may experience flu-like symptoms, weight reduction, anorexia, dry mouth, exacerbation of ulcerative gastrointestinal diseases, vomiting, pancreatitis, changes in liver enzymes, liver failure, dizziness, drowsiness, depression, blurred vision, convulsions, impotence, worsening circulation of the brain, retina artery thrombosis, arrhythmias, edema, heart attack, cardiac arrest or breathing, pneumonia, nasal discharge, acute renal failure, diabetes, hyperglycemia, leukopenia, anemia, hair loss, dry mucous membranes and skin, exacerbation of psoriasis, sarcoidosis ( rare), arthritis, vasculitis.

The injection site can be observed tissue necrosis, but it occurs very rarely.

Roferon Candles can cause a local allergic reaction.

 Roferon ampoule

Contraindications

Candles and Roferon injections are contraindicated in severe renal impairment, liver severe heart disease; convulsive disorders; dysfunction of the nervous system; In chronic hepatitis B or decompensated stage of this, which is accompanied by cirrhosis of the liver; chronic myelogenous leukemia - in the event that the patient to be bone marrow transplantation; in case of hypersensitivity to interferon alpha-2a and the other components of the drug.

In addition, Roferon according to the instructions can not be given to children under three years, because therein as excipient contains benzyl alcohol.

Combination therapy with Roferon and ribavirin is contraindicated in pregnant women.





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