Rifampicin

 Rifampin Capsules

Rifampicin - anti-bacterial anti-TB drug.

Pharmacological action

Rifampicin inhibits Mycobacterium tuberculosis, Brucella, chlamydia, legionella, rickettsia, Mycobacterium leprae, Staphylococcus, Clostridium, streptococcus, gonococcus, meningococcus.

Product form

Rifampicin release capsules, powders for dilution, tablets.

Indications for use of rifampicin

Antibiotics are used to treat all forms of TB, leprosy infections caused by bacteria sensitive to rifampicin and brucellosis. In most cases, the antibiotic administered as part of a treatment of these diseases.

There are good reviews of rifampicin as a prophylactic agent in meningitis. Antibiotics are used to prevent the development of disease in people who were in close contact with the bacilli carrier meningococcal or meningococcal meningitis cases origin.

Instructions Rifampicin: how to use

Tablets and capsules of rifampicin is recommended to take a half hour before eating.

In tuberculosis antibiotic combined with anti-TB drugs: ethambutol, streptomycin, isoniazid or pyrazinamide. Adult weighing less than 50 kg, is shown to take 450 mg of the antibiotic in knocking, if the weight is more than 50 kg - 600 mg.

Children, including newborn, a day can be given 10-20 mg of rifampin per kilogram. Acceptable daily dose thus - 600 mg.

For the treatment of lepromatous, borderline leprosy types adults recommend taking 600 mg of the drug. Take it once a month. Additionally appointed dapsone - 100 mg per day and Clofazimine - 300 mg per month and 50 mg per day. Children are given 10 mg of rifampin per kilogram body weight in combination with dapsone, clofazimine. The treatment lasts for at least two years.

For the treatment of tuberculoid, borderline tuberculoid type of leprosy adults should take 600 mg of rifampin per month and 100 mg dapsone daily. Babies give antibiotic once a month at a dose of 10 mg / kg, and dapsone - at a dose of 1-2 mg / kg. The treatment lasts six months.

In various infections caused by bacteria sensitive to the antibiotic, an adult patient is a dosage 0, 6-1, 2 g; child - 10-20 mg / kg. Take the drug twice a day.

If brucellosis shows the use of rifampicin at a dose of 900 mg per day. The therapy lasts 45 days.

Antibiotic is administered intravenously at a widespread and severe forms of pulmonary tuberculosis under difficult purulent processes or in cases where the pills or capsules are physically impossible for the patient.

The daily dosage for intravenous antibiotics - 0, or 0 45 g, 6 g (if the case is severe).

side effects

 Rifampicin 150 mg

Rifampicin can cause diarrhea, dizziness, nausea, blurred vision and appetite, fever, vomiting, headache.

There are reviews of rifampicin from taking his patients, indicating for antibiotic may appear erosive gastritis, start an allergic reaction, confusion, worsening of gout.

In overdose rifampicin swollen lungs, there confusion, convulsions. The patient was washed stomach, conduct enhanced diuresis, give activated charcoal.

Contraindications

Rifampicin is contraindicated according to the instructions in jaundice, chronic renal failure, severe cardiopulmonary diseases, infectious hepatitis, during pregnancy, breast-feeding.





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