Refortan (international name - HES) refers to a group of plasma-funds, which serves as a source of amylopectin potato, rice, corn and wheat. The drug has a long plasma-effect, improves blood circulation and its rheological properties.
Structure and Composition
The main active ingredient - HES '60
Supporting components: sodium chloride, purified water.
Refortan available as 6% and 10% solution for infusion in vials of 250-500 ml, placed on 10 pcs. in a cardboard box.
Pharmacological properties Refortan
Refortan a colloidal solution based macromolecular compound. The main substance of the drug have a long plasma-effect and can affect blood clotting.
Preparation restores blood flow through the vessels, which depends on the hydrostatic pressure in the portions of the circulatory system.
Refortan reduces blood viscosity, reduces the process of unification of platelet aggregation and eliminate red blood cells. The drug has a high level of portability and a small amount of side effects.
When mixed Refortan with other drugs must be met fully aseptic.
Refortan indicated for the prevention and treatment of disorders of the microcirculation and reduce circulating blood volume caused by trauma, burns, sepsis, etc.
The drug is effective for the prevention of high blood pressure during spinal and epidural anesthesia type.
Instructions for use Refortan
In accordance with instructions entered Refortan drip or bolus dose and at a speed that depends on the individual patient's indications. The first time is slowly added 10 ml of a solution to prevent anaphylactic shock.
In hemorrhagic shock solution Refortan administered at 20 ml / h, and during sepsis and burns speed must be reduced.
Adults and children over 12 years prescribed a daily dose of no more than 33 ml of a 6% solution or 20 ml of a 10% solution.
Patients with large blood loss physician must correctly identify the maximum speed of the introduction of the solution and its dosage.
According to the instructions Refortan during transfusion therapy (hemodilution) daily dose should be 500 ml for 3-5 days, with an average blood loss and up to 4 weeks for severe blood loss.
To treat hypovolemia administered 20 ml / kg of a 10% solution at 20 ml / hr. Duration of treatment is determined by the attending physician in accordance with the level of hypovolemia.
Contraindications to receiving Refortan are hypersensitivity and intolerance to the components of the drug, children up to 12 years, increased intracranial pressure, intracranial bleeding, kidney and liver failure, pulmonary edema, impaired blood clotting, hypokalemia, increased chloride and high sodium content in the blood plasma.
When pregnancy Refortan be used with caution, especially in the first trimester. The drug may interfere with fetal development in the appointment of his women for a period up to 14 weeks.
In the second and third trimester of pregnancy may be appointed Refortan physician with minimal risk to the fetus and high rates of therapeutic effect for the patient.
Side effects Refortan
Refortan may cause the following side effects:
- allergic reaction - hives, dermatitis, facial flushing, itching, angioedema, tachycardia, flu-like symptoms;
- on the part of the digestive system - nausea, vomiting, diarrhea, bleeding of the digestive tract;
- on the part of the circulatory system - increased activity of serum amylase, shock, hypoproteinemia;
- of the cardiovascular system - arrhythmia, heart failure, cardiac arrest;
- the central nervous system - neuralgia, myalgia, headache and dizziness, fainting, coma.