Rastan

 Rastan packaging

Rastan - recombinant growth hormone.

The composition of the melt and release form

The preparation is produced as a lyophilisate for solution for s / c administration to the applied white solvent. One vial contains the active drug component - somatropin - 4, 16 or 20 IU.

Auxiliary components: sodium hydroxide, sodium dihydrogen phosphate dihydrate, glycine, mannitol.

Solvent: water for injection 1 ml, 3 mg m-cresol.

The glass bottles together with the solvent.

Pharmacological action

Somatropin stimulates somatic and skeletal growth affects the metabolic processes. It promotes the growth of bones, providing action epiphysis plates of long bones. It stimulates the bone metabolism in children. By reducing body fat and increasing muscle mass there is a normalization of the body structure.

As replacement therapy in patients with osteoporosis and growth hormone deficiency normalizes bone density and mineral composition.

It increases the size and the number of muscle cells, gonads, liver, adrenal glands, thymus, thyroid. It promotes protein synthesis and transport of amino acids into the cell. It has an impact on the profile of lipoproteins and lipids, thereby reducing cholesterol levels. Helps delay in the body of phosphorus, potassium and sodium, inhibits the release of insulin. It increases muscle activity, body weight and physical endurance.

Indications Rastan

According to the instructions Rastan is shown in the following cases:

  • Turner's syndrome;
  • Growth hormone deficiency in children;
  • Congenital or acquired growth hormone deficiency in adults;
  • Chronic renal failure in prepubertal children.

Contraindications

According to the instructions Rastan is contraindicated in:

  • During pregnancy and lactation;
  • In malignant tumors;
  • For promoting growth in patients with closed epiphyseal growth zones;
  • When urgent conditions;
  • If a hypersensitivity to the drug.

Be wary appoint Rastan on instructions at:

  • Hypothyroidism;
  • Prader-Willi syndrome;
  • Craniocerebral hypertension;
  • Diabetes.

Dosing and dosing regimen Rastan

 Rastan 4ME

According to the instructions Rastan administered p / once a day, slowly, preferably at bedtime. In order to prevent lipoatrophy is recommended to periodically change the site of injection.

Dosage Rastan selected individually depending on the lack of growth hormone therapy efficiency and body weight.

The recommended dose for children with growth hormone deficiency - 25-35 mg per kg per day. Treatment should begin at the earliest possible age and continue until puberty or before the completion of bone growth. Upon reaching the desired effect possible discontinuation of treatment.

With a lack of growth hormone in adults for the initial dosage instructions Rastan is 150-300 mg a day with the subsequent increase. Maintenance dose is adjusted individually, but in most cases it does not exceed 1 mg per day.

In chronic renal failure in children, which is a consequence of growth retardation, as well as Turner's syndrome recommended dose is 45-50 mg per kg per day.

Side effects Rastan

Feedback from Rastan has the following side effects on different systems of vital activity:

  • Hyperglycemia, decreased thyroid function;
  • Vomiting, headache, nausea, blurred vision;
  • Fluid retention with the development of peripheral edema;
  • Leukemoid reaction;
  • Increased intracranial pressure;
  • Slipped capital femoral epiphysis of the femoral head.

Typically, these side effects of Rastan reviews are dose-dependent, transient, requiring dose adjustment.

In addition, reviews of Rastan can cause itching and a feeling of pain at the injection site.

Overdose

Acute overdose crease on responses may lead initially to hypoglycemia, then hyperglycemia. In addition, marked symptoms of an excess of growth hormone - gigantism or acromegaly, hypothyroidism, reducing the concentration of serum cortisol.





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