Pyrazinamide - synthetic anti-TB drug.
Mode of action of pyrazinamide
The active substance pyrazinamide has TB action. The drug, depending on the dose received may cause a bacteriostatic or bactericidal effect.
Pyrazinamide according to the instructions is very active in the acidic environment. Penetrating into the pockets of tuberculous lesions, effectively acts on intracellular mycobacteria located.
In combination with other anti-TB drugs reduced the likelihood of developing resistance.
Pyrazinamide released only in the dosage form of tablets containing 250 or 500 mg of active substance of the same name.
Pyrazinamide analogs are medicines Linamid, Pizina, Makrozid, pyrazinamide-Acre, Pirafat, STADA pyrazinamide, pyrazinamide, Nikki.
According to the instructions Pyrazinamide is prescribed for the treatment of tuberculosis, often in combination therapy.
The drug is not used when existing hypersensitivity to the active or auxiliary components pyrazinamide.
As a rule, pyrazinamide administered with caution in:
- Hepatic Insufficiency.
Ability to use pyrazinamide during pregnancy is solved individually as a doctor in the case of existing resistance to rifampicin, isoniazid and ethambutol.
Pyrazinamide for instructions should be taken in the morning, during or after a meal. The daily dose is usually 20-30 mg per 1 kg of body weight. The maximum daily dose of pyrazinamide should not exceed 2, 5 g, that a bad portability can be divided into 2-3 receptions. When conducted TB treatment can be applied multiple treatments:
- Once a week for 90 mg / kg;
- Twice a week, 3-3, 5 g;
- Three times a week for 2-2 5 g
Generally, treatment is three months pyrazinamide.
In old age, pyrazinamide on responses to effectively take a day not more than 15 mg / kg. Babies preparation of instructions administered once a day 15-20 mg / kg, the maximum - 1, 5 g
When TB treatment pyrazinamide administered with aminoglycosides, isoniazid and rifampicin.
Pyrazinamide on responses often causes digestive disorders that manifest themselves as:
- The aggravation of peptic ulcers;
- "Metallic" taste in your mouth;
- Liver tenderness;
- Yellow atrophy of the liver;
- Decreased appetite;
In addition, when receiving pyrazinamide for reviews can be observed:
- Irritability, dizziness, sleep disturbances, headache, depression;
- Splenomegaly, sideroblastic anemia, thrombocytopenia, porphyria, hypercoagulation, vacuolization of red blood cells;
- Myalgia, arthralgia;
- Interstitial nephritis, dysuria;
- Hives, skin rash;
- Acne, hyperuricemia, pyrexia, photosensitivity, exacerbation of gout.
Disorders of the central nervous system in the form of seizures, hallucinations and confusion occur rarely.
The risk of hypoglycemia increases diabetes mellitus.
In case of overdose of pyrazinamide instructions may increase the side effects of the central nervous system and liver function abnormalities develop.
In a joint application with rifampicin increases the likelihood of developing hepatotoxicity.
Storage conditions pyrazinamide
Pyrazinamide related to anti-TB drugs prescription. Do not store the tablets over 5 years.