Prestancia - drug combination of amlodipine and perindopril, which is used for the treatment of primary and secondary hypertension, angina pectoris, chronic ischemic heart disease. Prestancia refers to ACE inhibitors in combination, and calcium channel blockers in combination.
Pharmacological action Prestancia
Prestancia consists of two active components acting in different directions - anti-anginal and anti-hypertensive. We consider the effect of each component drug alone and in general.
Perindopril Prestancia inhibits kininazu II - the enzyme which converts angiotensin I to the vasoconstrictor, angiotensin II and destroys vasodilator bradykinin to inactive heptapeptide.
Inactivating bradykinin, ACE not only enhances the activity of circulating, and tissue kinin-kallikrein system, simultaneously with the activation of prostaglandins.
The therapeutic effect is due to inhibition of ACE perindopril active metabolite perindoprilat. Prestancia used for the treatment of any degree of complexity of hypertension. Its use reduces the diastolic and systolic blood pressure in the supine position and in the standing position. Reducing round, perindopril improves peripheral circulation, lowers blood pressure without affecting heart rate. By increasing the renal blood flow, the drug does not change while the glomerular filtration rate.
Perindopril in Prestancia dilates blood vessels, restores elasticity of the large arteries and structure of the vascular walls of small arteries, reducing left ventricular hypertrophy.
After single dose maximum antihypertensive effects achieved after 4-6 hours and lasts 24 hours. Very quickly, reducing blood pressure, a drug with a high enough efficiency continues to operate 24 hours after admission.
Less than a month from the start of the reception Prestancia therapeutic effect occurs. The drug is not addictive, cessation of use is not accompanied by a withdrawal syndrome.
Confirmed decrease of mortality due to diseases of the cardiovascular system and a significant reduction in the incidence of complications while taking perindopril.
Amlodipine in Prestancia blocks slow calcium channel dihydropyridine derivatives. At the level of the dihydropyridine receptor impedes the flow of calcium ions into smooth muscle cells of blood vessels and the myocardium. The antihypertensive action of amlodipine is prolonged and dose-dependent. By relaxing the smooth muscle of blood vessels, promotes the expansion:
- Major coronary arteries and arterioles (including areas in myocardial ischemia affected);
- Peripheral arterioles.
Effect of amlodipine on Prestancia sinus and atrioventricular nodes are poorly marked, slowing AV conduction slightly. Reduced Platelet Aggregation increases the glomerular filtration rate, accelerate the excretion of sodium and diuresis. As a result of the prolonged effect of blood pressure is reduced gradually, reflex stimulation of the sympathetic nervous system is minimal. When hypertension significantly reduced the degree of hypertrophic changes in left ventricular myocardium.
When angina and single daily dose of amlodipine Prestancia increases the total time of exercise, delay the onset of angina attacks, reducing their frequency, resulting in a reduced dose of nitroglycerin consumption.
When hypertension single daily dose will ensure a significant reduction in blood pressure for 24 hours standing and lying down, without causing acute hypotension because of the slow onset of action.
To prove the absence of negative effects on lipid levels in the blood plasma and metabolism, allowing prescribed to patients in the case of asthma, diabetes, and gout.
Prestancia - a combination of perindopril and amlodipine reduces:
- The frequency of attacks of angina pectoris;
- Risk of heart attack;
- Cardiovascular mortality.
Form release Prestancia
Prestancia white pills, biconvex, engraved on one side - the manufacturer's logo, on the other - the proportion of the content of perindopril / amlodipine. The form of tablets depends on this relationship:
- Oblong - 5/5;
- Square - 5/10;
- Triangular - 10/5;
- Round - 10/10.
Excipients: microcrystalline cellulose, lactose monohydrate, magnesium stearate, silica colloidal anhydrous.
Tablets Prestancia packed in polypropylene bottles with dispenser of 30 pieces, the bottle in a cardboard unit to control the first opening.
The analogue Prestancia on active current component - Dalnevost pills.
Analogs Prestancia mechanism of pharmacological effects of one subgroup - Triapin, Equator, Koripren, Ekvakard, Enanorm.
According to the instructions, Prestancia prescribed to patients:
- Ischemic heart disease with stable angina, requiring therapy with perindopril in combination with amlodipine.
According to the instructions, Prestancia not appointed in the case of:
- Angioneurotic edema (angioedema), provoked by the previous ACE inhibitor in history;
- Hereditary or idiopathic angioedema;
- Hypotension (DM less than 90 mm Hg);
- Shock, including cardiogenic;
- Outlet obstruction way the left ventricle (aortic stenosis, or the like.);
- Unstable angina (except Prinzmetal's angina);
- Heart failure after acute myocardial infarction (first 28 days);
- Pregnancy and lactation period;
- Hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
- Renal failure (creatinine clearance less than 60 mL / min);
- The age of 18 years (safety and efficacy have not been studied);
According to the instructions, Prestancia not indicated for hypersensitivity to amlodipine (other derivatives dihydropiridine) to perindopril (other ACE inhibitors), a part of the drug excipients.
According to the instructions, Prestancia take 1 tablet per day in the morning before eating. The ratio of components and the duration of therapy is determined by the doctor.
According to reviews, Prestancia often causes:
- Drowsiness, headache, dizziness;
- Visual disturbances;
- Noise in ears;
- Palpitations, flushing, reduction of blood pressure;
- Shortness of breath, cough;
- Abdominal pain, nausea, vomiting, diarrhea, constipation;
- Itching, rash;
- Muscle spasms.
Also Prestancia, reviews, sometimes causing other disorders. In case of any symptoms of side effects should immediately consult a doctor.
When hypertension or coronary artery disease Prestancia, reviews, helps to improve the well-being and stabilization for a long time.
Storage conditions Prestancia
Prestancia should be stored out of the reach of children, at a temperature no higher than 30 ° C, in the original packaging, the bottle must be kept tightly closed. Shelf life 2 years.