Pradaksa

Pradaksa - antithrombotic and anticoagulant drug used in traumatology and orthopedics for the prevention of venous thromboembolism in the postoperative period. Drugs Warfarin Fenilin and Marcumar - Pradaksy counterparts. Some comments about Pradakse says that the drug from all known coagulants most efficient and modern.

 Pradaksa used for the prevention of venous thromboembolism in the postoperative period
 Available in solid drug capsules with opaque blue cap. Inside the capsules are pellets yellow. Dabigatran etexilate - the main active ingredient of the drug.

The pharmacological action of the drug Pradaksa

Effect of the drug is to suppress the activity of thrombin. Dabigatran etexilate - small molecule that does not have pharmacological activity. After oral administration, the compound is very rapidly absorbed and converted to dabigatran hydrolysis. Dabigatran - active, competitive, reversible direct thrombin inhibitor. This substance inhibits the activity of thrombin, fibrin binding free thrombin and also inhibits platelet aggregation induced by thrombin.

In a review of medical Pradakse said that the effectiveness of this drug is reduced to 20% of body weight over 120 kg. When the body weight of about 48 kg of drug efficacy is increased by 25% (compared with patients with an average body weight).

Indications for use of the drug Pradaksy

The instructions to Pradakse ukazvaetsya that the drug should be prescribed for the prevention of venous thromboembolism or systemic patients undergoing orthopedic surgery. Pradaksu sometimes prescribed for patients with atrial fibrillation to reduce death rates from cardiovascular diseases.

Pradaksa - Instructions for use

According to the instructions, Pradaksu capsules to be taken once or twice a day (regardless of the meal). The capsules do not open, and drink plenty of fluids.

For the prevention of venous thromboembolism recommended intake of 220 mg once a day (2 capsules of 110 mg). Patients with moderate renal impairment Pradaksy dose should be reduced to 150 mg (two capsules of 75 mg).

After knee replacement medications should be started within one to four hours after the operation. Immediately after surgery, it is recommended to take one capsule per day of the preparation (110 mg), and then to increase the dose two capsules daily. Course duration is ten days or 28-35 days (after hip replacement).

Patients with atrial fibrillation Pradaksu be taken twice a day in a daily dose of 300 mg.

Contraindications Pradaksy

According to the instructions, and analogues Pradaksu Pradaksy can not be taken for a known hypersensitivity to any component of the funds under severe renal failure, the active clinically significant bleeding, pharmacologically induced or spontaneous breaking of homeostasis. Do not use the drug in the human liver, malignant tumors, as well as intracranial hemorrhage in history, spinal injuries or brain injuries in history, ulcers of the gastrointestinal tract, oesophageal varices, intracranial or intraspinal vascular disorders.

The simultaneous use of antiplatelet agents Pradaksy and increases the risk of bleeding tripled. Contraindicated the use of this drug in combination with other anticoagulants.

No clinical data on the effects of taking this medication by patients under the age of 18 years.

Precautions

 Pradaksu can be used in patients with atrial fibrillation
 Pradaksu Pradaksy and analogs should be used with caution in conditions associated with an increased risk of bleeding. In the period of treatment may develop bleeding of different localization. Reducing the concentration of hematocrit and / or hemoglobin in the blood, which is accompanied by a decrease in blood pressure, it is the basis for the search of the source of bleeding.

Side effects Pradaksy

In many reviews of Pradakse it says that long-term use of the drug for prevention is sometimes accompanied by the appearance of urticaria, rash, pruritus, bronchospasm, diarrhea, abdominal pain, dyspepsia. Sometimes while taking this drug develop thrombocytopenia, anemia, gastroesophageal reflux disease, gastroezofagit, hyperbilirubinemia, hematuria, urogenital bleeding, cutaneous hemorrhagic syndrome.

Storage conditions Pradaksy

Pradaksu in bottles or blister packs stored at a temperature no higher than 25 ° C. Keep the tool should be no longer than three years. After opening the vial is recommended to use the drug for a month.





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