Platifillin

 Platifillin solution

Platifillin - pharmacological agents from the group of m-anticholinergics, has antispasmodic and mild sedative effect.

Structure and Composition

According to instructions issued Platifillin ampoules as a solution for parenteral administration. In 1 ml ampoule 1 0 2% drug (2 mg platifillina and water for injection).

Externally Platifillin is a colorless, odorless clear liquid.

It produced the drug for 10 ampoules in a carton box, and the instructions for use, ampoule knife or lancet. If the package ampoules points or rings for an autopsy, the ampoule opener can not be embedded.

Pharmacological action platifillin

According to the instructions Platifillin is a blocker of M-cholinergic receptors and has antispasmodic effect in the smooth muscle of the digestive tract and bronchus, and has little sedative (sedative) action. This drug reduces the secretion of bronchial, salivary, lacrimal glands and sweat glands. In addition, Platifillin able to expand the pupil and induce mild paralysis of accommodation. This drug may increase intraocular pressure.

Indications

Indications for platifillin are the following conditions:

  • cramps of the digestive system (liver colic, intestinal dyskinesia, biliary dyskinesia);
  • comprehensive treatment of gastric ulcer and duodenal ulcer;
  • renal colic;
  • bronchospasm in patients with diseases of the respiratory system (such as an adjuvant treatment).

Contraindications platifillin

This drug has a rather broad contraindications, so its use without a doctor's prescription is unacceptable. Platifillin contraindicated for use in the following conditions:

  • hypersensitivity to platifillin;
  • angle-closure glaucoma;
  • expressed atherosclerosis, chronic heart failure II-III degree;
  • cardiac arrhythmias, tachycardia;
  • benign prostatic hyperplasia;
  • signs of kidney / liver failure;
  • diaphragmatic hernia with symptoms of reflux esophagitis;
  • atony of the intestines;
  • gastrointestinal bleeding;
  • ulcerative colitis;
  • elderly age.

You should carefully weigh the evidence to platifillin during pregnancy and lactation, coronary heart disease, mitral stenosis, hypertension, hyperthyroidism, digestive system diseases with symptoms of obstruction (pyloric stenosis, gastric, esophageal achalasia, and others.), Increased body temperature, age 40 years (there is a risk of undiagnosed glaucoma). Also, caution should be used with this drug in patients with ulcerative colitis, myasthenia gravis, urinary retention history, chronic lung disease, Down syndrome, cerebral palsy, and in patients with early childhood.

Dosing and Administration

 Platifillin ampoule

According to the instructions Patifillin may be administered subcutaneously, intramuscularly.

For the relief of acute pain in the abdomen, caused by hepatic or renal colic, as well as peptic ulcer disease, it is recommended to inject the drug subcutaneously at a dose of 2.1 mL (2.4 mg) 2-3 times a day. The course of treatment can be up to 10 days. The maximum daily dose for an adult - 30 mg (15 ml of the drug), a single dose should not exceed 10 mg (5 ml).

For children Platifillin applied in the following dosages:

  • up to 1 year - unit dose 0, 035 mg / kg, the maximum daily - 0, 07 mg / kg;
  • 1-5 years - a single dose of 0, 03 mg / kg, the maximum daily 0, 06 mg / kg;
  • 6-10 years - a single dose of 0, 025 mg / kg, the maximum daily 0, 05 mg / kg;
  • 11-14 years - 0, 02 mg / kg, the maximum daily dose for this age of 0, 04 mg / kg.

Side effects platifillin

According to the instructions Platifillin can cause side effects such as dry mouth, decreased blood pressure, tachycardia (rapid heart rate), dizziness, headache, cramps, urinary retention, pulmonary atelectasis. In the opinion of Platifillin rarely causes side effects in younger patients, mostly adverse reactions may occur in elderly patients with severe somatic pathology.

Overdose

In overdose platifillin may develop paralytic ileus, urinary retention occur (in patients with benign prostatic hyperplasia), paralysis of accommodation, increased intraocular pressure, dry mucous membranes of the mouth, swallowing disorder, mydriasis (pupil dilation until the disappearance of the iris), tremors, convulsions , fever, excitation / inhibition of the nervous system, the effects on the respiratory center suppressing the activity of vasomotor center.

Treatment of overdose is reduced to the use of forced diuresis, administration holinostimulyatorov and anticholinesterase drugs. When the temperature of the body recommended antipyretic drugs, wet wiping. When excited by a patient shows the introduction of an intravenous solution of sodium thiopental. If mydriasis should drip eye drops physostigmine, pilocarpine, phosphacol.

Interaction platifillin with other drugs

It is known that the use of platifillin with phenobarbital, magnesium sulphate and chloride etaminalom enhances their hypnotic and sedative effect.

Simultaneous use with other m-holinoblokatorami, haloperidol, phenothiazines, MAO inhibitors, tricyclic antidepressants and some antihistamines increases the risk of adverse reactions.

Anticholinesterase drugs are antagonists platifillin.

It is known that morphine in combination with the drug enhances the inhibitory effect on the cardio - vascular system.

Analgesics, sedatives with platifillin increase its antispasmodic effect.

When vascular spasm Platifillin good use in combination with antihypertensive drugs and sedatives.

Cautions

During treatment platifillin, reviews need to refrain from driving motor vehicles and other work that requires attention.





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