Piroxicam

 Piroxicam capsules
 Piroxicam - nonsteroidal anti-inflammatory drug from the group of oxicams.

The composition of piroxicam and the release form

The drug is released in the form of hard gelatin capsules containing the active ingredient - Piroxicam 10 or 20 mg. Auxiliary components: magnesium stearate, talc, microcrystalline cellulose, glycine, wheat starch, colloidal silica.

The blister packs of 10 pieces.

Pharmacological action

The active ingredient of the drug belongs to a group of oxicams. It has antipyretic, analgesic and anti-inflammatory effect.

The principle of action is associated with inhibition of COX enzyme, thus inhibition of prostaglandin synthesis occurs from arachidonic acid.

In the systemic application of piroxicam reduces pain, inhibits platelet aggregation, reduces or eliminates or reduces pain and inflammation in the joints and reduces swelling and morning stiffness of the joints.

In the opinion of piroxicam analgesic effect of its use comes in half an hour. Anti-inflammatory effect appears at the end of the first week of use.

Indications for use Feldene

According to the instructions prescribe piroxicam in the following cases:

  • diseases of the soft tissues: tendonitis, bursitis, periarthritis;
  • gout;
  • post-traumatic conditions: pain in sprains, fractures, sprains;
  • arthropathy: Reiter's syndrome, rheumatoid arthritis, ankylosing spondylitis, arthritis, chronic arthritis, psoriatic arthritis;
  • cystitis, adnexitis, dysmenorrhea;
  • sciatica, lumbago, neck-shoulder syndrome;
  • pain after dental, surgical, gynecological and orthopedic surgery.

Dosing piroxicam and dosing regimen

 The anti-inflammatory drug piroxicam
 According to the instructions piroxicam taken orally once a day during a meal or divided dose into two doses. The maximum daily dose is 20 mg.

With much of clinical symptoms may increase the dose to 40 mg per day.

Contraindications

According to the instructions piroxicam has the following contraindications:

  • ulcer 12 duodenal ulcer and stomach in the acute phase;
  • pregnancy and breastfeeding (lactation);
  • disruptions in the peripheral blood of unknown nature;
  • indicate a history of acute rhinitis, asthma, urticaria, associated with the intake of vitamin C and other NSAIDs;
  • expressed by the human kidney and liver;
  • hypersensitivity to piroxicam;
  • age up to 15 years.

With care prescribe piroxicam according to the instructions:

  • patients with hypertension, infectious diseases, diseases of the gastrointestinal tract in history, chronic heart failure and elderly patients;
  • patients with allergic rhinitis, chronic obstructive airways disease, nasal polyposis, asthma.

During the period of Feldene is prohibited to drink alcohol and control the complex mechanisms that require high concentration of attention.

side effects

In the opinion of piroxicam may cause the following side effects of the different systems:

  • disorientation, headache, drowsiness, dizziness;
  • nausea, diarrhea, vomiting, heartburn, erosive and ulcerative lesions of the gastrointestinal tract associated with perforation and bleeding;
  • hives, itching;
  • photosensitivity.

Renal failure, anemia and granulocytopenia piroxicam of reviews is rare.

Overdose

Feldene overdose of reviews causes the following symptoms:

  • tonic and clonic convulsions;
  • aplastic anemia;
  • melena;
  • vomiting, nausea;
  • noise in ears;
  • meneropodobnye phenomenon;
  • agranulocytosis;
  • bullous or petechial rash;
  • tifo- or morbilliform skin rash;
  • hemorrhagic diathesis;
  • toxic and allergic shock.

Drug Interactions

The simultaneous use of piroxicam:

  • nalidixic acid, oral anticoagulants, oral hypoglycemic agents, sulfonamides, cyclophosphamide and triiodothyronine causes an increase in their concentration in the blood plasma;
  • Valium and other NSAIDs can cause the likelihood of side effects from the gastrointestinal tract and allergic reactions;
  • antihypertensive drugs and diuretics cause weakening of their actions;
  • lithium therapy causes an increase in the concentration of lithium in the blood plasma.

Conditions and terms

The drug is stored in a cool dark place for no longer than 36 months.





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