Pimafucin

Pimafucin - pharmacological agents from the group of antifungal antibiotics.  Pimafucin cream

Structure and Composition pimafutsin

According to the instructions Pimafucin comes in the form of vaginal suppositories, tablets for oral administration, and creams for topical use. The active ingredient of the drug - natamycin.

In one vaginal suppository contains 100 mg of natamycin and auxiliary components (cetyl alcohol, tallow, polysorbate, sorbitol, sodium hydrogen carbonate, adipic acid). Produced candles Pimafucin contour bezgyachakova package of 3 suppository. In a cardboard box 1 or 2 packages.

1 tablet contains pimafutsin 100 mg of active ingredient and auxiliary ingredients (potato starch, the magnesium stearate, PVP, lactose, gelatin, calcium carbonate, kaolin, talc, triacetin, cellulose acetate phthalate, white bees wax, titanium oxide, sucrose). Produced tablets Pimafucin in enteric-coated tablets in bottles of 20, together with instructions for use.

Cream Pimafucin designed for outdoor use. 1 g of cream contains 20 mg of natamycin and auxiliary components (decyl oleate, cetostearyl alcohol, waxes, sodium lauryl sulfate, propylene glycol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, water). Produced cream in tubes of 30 g, in a cardboard box 1 tube with instructions for use.

Pharmacological action

According to the instructions Pimafucin has antimicrobial and antiparasitic activity. This drug belongs to the antifungal antibacterial macrolide. Pimafutsin fungicidally effective, it destroys the integrity of cell membranes and thus leads to the death of microorganisms. To this drug sensitive pathogenic yeasts (particularly the genus Candida), less sensitive to it dermatophytes. Currently, it is not revealed resistance to microbial natamycin.

When the pill inside Pimafutsin operates only in the intestine, the drug is not absorbed from the digestive system into the systemic circulation.

When applying a cream or application pessaries Pimafutsin also not absorbed into the bloodstream.

Indications pimafutsin

Indications for use of pimafutsin instructions are fungal diseases of the skin and mucous membranes:

  • Acute candidiasis (pseudomembranous and atrophic) in patients with immunosuppression, malnutrition, as well as after treatment with antibacterial drugs, cytostatics, corticosteroids;
  • ear infections caused by fungal infections or candidiasis complicating;
  • candidiasis of skin and nail;
  • intestinal candidiasis;
  • vaginitis, vulvitis, vulvovaginitis, caused by fungi of the genus Candida;
  • ringworm.

Contraindications

Hypersensitivity to ingredients pimafutsin.

Application pimafutsin during pregnancy and lactation

Currently approved for use during pregnancy pimafutsin. The drug is not absorbed into the systemic circulation and may exert adverse effects on the fetus. It is also possible to use pimafutsin in lactating women.

Dosing and Administration

When ringworm (and candidiasis of the skin and nails) Pimafucin prescribed a cream. It is applied to the affected surface one or more times per day.

When Candida diaper dermatitis in children is also recommended to use Pimafucin once or several times a day. This drug is approved for use from birth.

In the treatment of intestinal candidiasis Pimafucin recommended to take 1 tablet (100 mg) four times a day, course of treatment an average of 7 days. Children older than 6 years appoint 1 tablet 2 times a day.

When treating otomycosis recommended skin surface of the ear lubricated cream once or several times a day. After using the recommended pimafutsin put into the ear canal turunda of cotton or wool.

In the treatment of vaginitis, vulvitis recommended to enter one suppository at night for 3-6 days. Enter suppository is necessary in the supine position deep into the vagina. When thrust during vaginal candidiasis is recommended to complement the treatment of tablets pimafutsin inside (100 mg four times a day for 10-20 days).  Pimafucin pills

For the treatment of vulvovaginal lesions of the external genitalia should use cream Pimafucin.

Side effects pimafutsin

In the opinion of Pimafucin rarely causes side effects. From the digestive system may cause nausea and diarrhea (with pill of this drug). Usually these events are themselves and do not require discontinuation of the drug.

Local reactions at Pimafucin, reviews occur rarely, and as manifested in the form of lung irritation or burning sensation.

Overdose

Currently there are no reports of overdose with this drug.

Interaction pimafutsin with other drugs

Pimafutsin Interactions with other drugs have not been described.

Cautions

Pimafutsin vaginal suppositories according to the instructions quickly dissolve to form frothy, allowing the active agent evenly distributed along the walls of the vagina. In chronic and recurrent form of Candida infection recommended combination therapy using pills or creams.

During menstruation treatment pimafutsin advisable to interrupt.

You should also examine both sexual partners in the presence of Candida infection and treat both. During the application pimafutsin partners should use a barrier method of contraception.





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