Phenylbutazone

Pharmacological action

 Phenylbutazone ointment

Phenylbutazone is a non-steroidal anti-inflammatory agent of synthetic origin.

This drug has a pronounced analgesic, anti-inflammatory, analgesic and antirheumatic action. The active substance Phenylbutazone is phenylbutazone, which inhibits the activity of cyclooxygenase and reduces the synthesis of prostaglandins. Application of Phenylbutazone can reduce pain, inflammation, restore mobility of the joint. In addition, drug for gout increases the excretion of urate excretion in 2-3 times, reducing their level in the blood. Reduce pain and inflammation Phenylbutazone helps with thrombophlebitis of hemorrhoidal veins and obstetric-gynecological origin, postoperative thrombophlebitis.

Indications for use of phenylbutazone

Phenylbutazone ointment is assigned in the following cases:

  • articular syndrome in osteoarthritis, acute gout, rheumatoid arthritis, ankylosing spondylitis;
  • pain in myalgia, arthralgia, phantom pain, neuralgia;
  • dermatitis, thermal and solar burns, insect bites, skin inflammation by local intramuscular and intravenous injection;
  • thrombophlebitis, inflammation of hemorrhoids;
  • soft tissue injury, hematoma, inflammatory infiltrates (accumulation of cellular components in tissue);
  • stretching the tendons and muscles, tenosynovitis (inflammation of the membranes surrounding the tendon), bursitis (inflammation of periarticular bag).

Phenylbutazone take pills at:

  • gouty, rheumatoid, psoriatic arthritis, osteoarthritis, ankylosing spondylitis, arthritis, systemic lupus erythematosus;
  • tenosynovitis, bursitis, myalgia, arthralgia, neuralgia;
  • the pain of burns and injuries, menstrual, dental, and headache;
  • fever that accompanies colds and infectious diseases.

Instructions for use Phenylbutazone

 Phenylbutazone Tablets
 Phenylbutazone ointment should be applied 2-3 times a day. Superficial lesions do not require rubbing the drug, and with deep processes need to rub ointment Phenylbutazone until complete absorption.

Phenylbutazone tablets administered 200-400 mg (1 tablet - 150 mg) 3-4 times a day. Oral Phenylbutazone should be made during or after a meal. Children older than six months, the recommended single dose of 10 - 100 mg which should be taken 3-4 times a day. Usually 2-5 weeks is sufficient to secure the therapeutic effect of Phenylbutazone tablets.

side effects

Application in the form of ointments phenylbutazone can cause allergic skin reactions.

Tablets Phenylbutazone can cause undesirable effects such as:

  • nausea, vomiting, heartburn, abdominal pain, constipation, diarrhea, indigestion;
  • aphthous stomatitis (with small ulcers), erosive esophagitis (erosion on the esophageal mucosa), glossitis (inflammation of the tongue), gingival, gastrointestinal, hemorrhoidal bleeding, abnormal liver function;
  • tachycardia, increased blood pressure;
  • agitation, drowsiness, dizziness, headache, drowsiness;
  • tinnitus, hearing loss;
  •   anemia, leukopenia, agranulocytosis;
  • bronchospasm, itching, skin rash, pruritus, angioedema, edema syndrome;
  • uterine bleeding, increased sweating.

Contraindications to the use of phenylbutazone

Instructions for Phenylbutazone is not recommended to use the drug in the form of an ointment with trophic ulcers, eczema, violation of the integrity of the skin.

From the use of phenylbutazone should be discarded in case of hypersensitivity to phenylbutazone. Precautions Phenylbutazone ointment prescribed to pregnant and lactating women.

According to the instructions, in the form of tablets Phenylbutazone is contraindicated in:

  • violation of kidney and liver function;
  • gastric ulcer and duodenal ulcer;
  • circulatory failure, the second and third stages;
  • diseases of the hematopoietic organs;
  • arrhythmia;
  • aspirin-induced asthma.

Precautions Phenylbutazone tablets administered in the following cases:

  • bronchial asthma;
  • hyperbilirubinemia;
  • arterial hypertension;
  • swelling;
  • congestive heart failure;
  • hemophilia;
  • renal insufficiency;
  • blood diseases;
  • hearing loss;
  • diabetes;
  • diseases of the gastrointestinal tract;
  • stomatitis;
  • lactation;
  • pregnancy.

Additional Information

Storage of the drug should be carried out in a dark, cool and dry place.

Shelf life of the drug, according to the instructions Phenylbutazone, in the form of ointments - 5 years in the form of tablets - 3 years.





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