Phenylbutazone - analgesic, anti-inflammatory and antipyretic.
The drug belongs
to the group of NSAIDs from the group butadiona.
Its mechanism of action is associated with indiscriminate effects on tissue enzymes - cyclooxygenase 1 and 2 diabetes. Cyclooxygenase is contained in the endothelium (the inner lining) of blood vessels. Phenylbutazone blocks its action, resulting in impaired formation of prostaglandins from arahidonovoykisloty. Prostaglandins are a group of compounds that can cause inflammatory reactions in the body. By reducing their education, phenylbutazone has antipyretic, anti-inflammatory and analgesic effects. By the force of anti-inflammatory effect it is superior to aspirin.
We know about the properties of phenylbutazone increase excretion of uric acid from the body.
When receiving the drug inside the maximum content of active substance in the blood found after 2 hours. Conversion phenylbutazone occurs in the liver. Elimination from the body is carried out by the kidneys and intestines, partly in an unaltered state.
Form release phenylbutazone
By phenylbutazone instructions available in tablets of 150 mg of ointment for external use, 15% and 20% solutions for injections in ampoules.
Indications for use of phenylbutazone
The drug is prescribed inside in diseases such as nodular erythema, chorea, rheumatic fever, a non-specific infection and psoriatic arthritis. It must be remembered that this is an anti-inflammatory reserve, it is used in case of failure of other drugs and only a short-lived course. It is best manifested in the anti-inflammatory effect of ankylosing spondylitis and gout.
As an adjunct drug sometimes used in the treatment of arthritis and synovitis.
Topical application of ointments phenylbutazone helps with dermatitis from mechanical impact, minor burns 1 - 2 degrees, including solar, tensile tendons, muscles, insect bites.
Phenylbutazone according to the instructions can not be taken orally in case of hypersensitivity to it and other NSAIDs, in the case of severe renal or hepatic impairment, inhibition of the hematopoietic system (including the leukopenia), an exacerbation of duodenal ulcer and stomach, ulcerative colitis, with cardiovascular disease decompensated. The ointment is not applied in violation of the integrity of the skin, eczema, trophic ulcers.
Phenylbutazone can be used in adults and children older than 14 years.
To use caution in diseases of the central nervous system drug, gastritis it can provoke bleeding. During treatment to avoid water retention is recommended to limit the use of salt.
The appointment of the drug during pregnancy and lactation is possible only under medical supervision, after weighing the risk / benefit for the fetus and child.
Instructions for use phenylbutazone
Phenylbutazone as a tablet taken orally during a meal or immediately after with water.
The adult dose
is 100 - 150 mg 2 - 3 times a day (maximum - 600 mg / day). Once achieved clinical response, the dose should immediately be reduced to 200 mg / day.
Children dosage depends on the age of 10 - 100 mg in 3 - 4 divided doses.
The ointment is applied in a thin layer on the intact skin 2 - 3 times a day.
Injections are only for relief of acute symptoms of gout, rheumatoid arthritis, minor chorea.
In simultaneous reception with indirect anticoagulants, sulfonamides and antidiabetic agents intensified their action. Fenilbutazonsposoben influence the concentration and reaction speed.
Because of the deterioration in renal blood flow reduces the effectiveness of the drug diuretics and antihypertensives.
Phenylbutazone often causes adverse effects. Up to 45% of patients were impaired hematopoiesis (aplastic anemia, leukopenia), dyspepsia as nausea, abdominal pain, vomiting, diarrhea, neuritis, the formation of ulcers and erosions in the digestive tract, blood in the urine.