Pentas

Pentas - pharmacological agents from the group of anti-inflammatory drugs used to treat inflammatory bowel diseases.

Structure and Composition

 Pentas
 According to the instructions of the pentasil available as tablets with sustained release 500 mg. The active ingredient - mesalazine.

1 tablet contains 500 mg of mesalazine, as well as auxiliary components (ethyl cellulose, povidone, magnesium stearate, microcrystalline cellulose, talc).

Pentas Tablet looks like a flat cylinder of yellowish-gray with uneven staining, odorless. On one side of the tablet there is a risk for the division.

Preparation produced in blisters made of aluminum foil (10 tablets) in one package pentasil 10 blisters.

Pharmacological action Pentas

This drug has anti-inflammatory action. The active substance (mesalazine) inhibits leukocyte chemotaxis (movement of them from the bloodstream into the damaged tissue), the production of enzymes reduces inflammation (leukotriene. Cytokines) and displays the body of free radicals.

The local contact with the tablet Pentas intestinal mucosa takes place the separation of micro-granules. Of the mesalazine release granules slow that provides the therapeutic effect of the drug throughout the intestine (from the duodenum to the rectum) with any indicators pH. About 50% pentasil drug is released in the small intestine and colon.

This drug does not penetrate the blood-brain barrier. According to the instructions of the pentasil displayed in the kidneys and intestines.

Indications

  • Crohn's disease (any localization);
  • ulcerative colitis.

Contraindications Pentas

According to the instructions of the pentasil, the drug is contraindicated in patients with hypersensitivity to the ingredients, as well as in patients with severely impaired hepatic function, and \ or kidneys.

Use during pregnancy and lactation

According to the instructions of the pentasil not cross the placental barrier and is not teratogenic. However, use of this drug during pregnancy is possible only when the potential benefits of the pentasil higher risk of adverse reactions.

It is known that the pentasil partially excreted in breast milk, but no data on the adverse effects of the drug on the neonate does not currently received.

Dosing and Administration Pentas

According to the instructions of the pentasil tablets should be swallowed whole. Do not chew the tablets, this will break the pharmacokinetics of the drug.

To facilitate swallowing acceptable tablet divided into several parts or be dissolved in water immediately before ingestion.

If by chance you missed a pill one Pentas, it should be taken at any time, or the next reception, along with other tablets of the drug.

In the treatment of ulcerative colitis the dose selected pentasil doctor individually. Typically, in the acute stage is assigned to 4 g of the drug per day (divided into several doses). Kids in the acute stage of the disease the dose is calculated from the formula of 20-30 mg / kg / day.

For maintenance therapy pentasil administered in a dose of 2 g per day (divided into several doses). Babies calculation formula used maintenance dose of 20 mg / kg / day.

In the treatment of Crohn's disease dose pentasil selected physician on an individual basis depending on the severity of clinical symptoms and severity of the disease. According to the instructions of the pentasil maximum dose in the treatment of this disease is 4 grams per day. Children dosage is adjusted individually based on the characteristics of the disease and the patient's weight. Usually the drug is assigned on the basis of the formula of 20-30 mg / kg / day.  500 mg Tablets pentasil

side effects

According to reviews Pentas well tolerated and rarely causes side effects. Typically, the frequency of side effects does not exceed 1-3%. There may be abdominal pain, nausea, vomiting, diarrhea, headache. Also, allergic reactions may occur in the form of rash, urticaria and itch.

In the opinion of the pentasil rarely causes side effects such as arthralgia and myalgia, hair loss, liver and kidney, shortness of breath, pancreatitis, as well as changes in laboratory blood tests.

Overdose Pentas

There is no data on overdose with this drug. Theoretically signs of overdose can be significant side reactions. Treatment is symptomatic, with laboratory monitoring of the renal function.

Cautions

In severe renal impairment is not recommended to use the drug Pentas.

During the course of therapy should be regularly (especially at the beginning) to control the level of creatinine and urea in the blood serum.

In the event of changes in the formula of blood, as well as the symptoms of myocarditis should be discontinued the drug.

Pentas drug is not recommended for use in children younger than 2 years.

Acceptance of the drug does not affect the ability to drive vehicles and other moving machinery.

Interaction Pentas with other drugs

No data on the interaction of the pentasil with other drugs.





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