PegIntron

Pharmacological action

 Lyophilisates for solution
 PegIntron - medication with immunomodulatory effects.

Pharmacological action

The active ingredient of the drug - recombinant interferon alpha-2b, which inhibits hepatitis B and C, stimulates the immune system.

Product form

PegIntron is produced in the form of a lyophilized powder for further breeding and injections.

Indications

Treatment PegIntron effective for chronic hepatitis B and C, but only in cases where the patient is decompensated liver disease.

In most cases for the treatment of chronic hepatitis C combined with PegIntron drug ribavirin.

PegIntron Guide: how to use

PegIntron in chronic hepatitis B is administered subcutaneously at a dosage of 1-1, 5 micrograms per kilogram of patient body weight. Inject the drug 24-52 weeks once a week.

In chronic hepatitis C PegIntron administered in a dosage of 0, 5-1 mg / kg. The drug half inject subcutaneously once every 7 days. If after six months of therapy in the patient's blood is still detected viral RNA, treatments extend: the drug is administered weekly at the same dose for another six months. If after a year of treatment the virus is detected, treatment with PegIntron stopped.

During treatment permitted adjustment of drug dosage downwards - depending on the condition of the patient and laboratory data.

Judging by the reviews of PegIntron, a place for subcutaneous injection each time it is desirable to select a new - in order to avoid the appearance of irritation and pain at the injection site.

During the combination therapy, the dosage instructions for PegIntron is 1, 5 mg / kg of patient weight. One drug is administered once a week.

The dosage of ribavirin depends on the patient's weight, take it inside on a daily basis. Patients weighing less than 65 kg may take 800 mg ribavirin per day; Patients weighing 65-85 kg - 1,000 mg; Patients weighing more than 85 kg - 1200 mg.

PegIntron Powder for solution for injections can be mixed only with the diluent provided. The mixing in the same syringe PegIntron and other drugs is not allowed. The dissolution time of the powder - no more than 10 minutes. The remaining solution in the syringe is recyclable, it can not be reused.

Side effects of PegIntron

 The drug with immunomodulating effects
 PegIntron treatment may cause irritability, fatigue, dizziness, joint pain, insomnia, diarrhea, sore throat, headaches, anxiety, hair loss, malaise, cough, constipation, high blood pressure, chest pain, skin rash, vomiting, drowsiness, dyspepsia, heavy menstrual bleeding, menstrual irregularities, weight reduction, pain in the eyes, conjunctivitis, nasal congestion.

There are reviews of PegIntron, confirming that the drug can cause more serious side effects: hallucinations, psychosis, aggression, suicidal thoughts.

In patients undergoing combination therapy can begin tremors, loss or hearing loss, stomatitis, glossitis, prostatitis, bronchitis, runny nose, and can be observed increased fragility of hair, sensitivity to light, excessive thirst, increased blood pressure.

Cases where patients inadvertently taken at a dose of PegIntron, exceeding the therapeutic (in some cases - twice). Serious side effects do not arise here. It noted deterioration of health, but all the symptoms have passed on their own, without any consequences. Reviews of PegIntron from the patients exceeded the dose of medication, confirm that the treatment in this case, you can not stop.

Contraindications

PegIntron is contraindicated according to the instructions in autoimmune and severe mental illness, severe cardiovascular diseases, disorders of the thyroid gland, kidneys and nervous system, decompensated liver disease, epilepsy, hypersensitivity to interferon.

During pregnancy, lactation can not take medicine.





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