Pancreatin - a drug that improves digestion.
Structure and Composition
Pancreatin is produced in the form of biconvex tablets coated light pink color. The structure of 1 part powder pancreatin tablets 192 mg. Auxiliary components: sodium chloride, microcrystalline cellulose, magnesium stearate, colloidal silica, talc, titanium dioxide, oydragit L 30 D-55 or oydragit L-100, acid red 2 C croscarmellose sodium.
Use of Pancreatin helps digestion. Compensates for lack of pancreatic enzymes, has proteolytic, amylolytic and lipolytic effect, increases the breakdown of carbohydrates, proteins and fats in the duodenum 12, so is their more complete and rapid absorption. It normalizes digestion and improves the functioning of the gastrointestinal tract.
The composition of such enzymes include pancreatin alpha-amylase, protease (chymotrypsin and trypsin), lipase.
In the context of the normal intestinal microflora amylase breaks down starch into dextrins first, and then to maltose.
Due lipase neutral fat is cleaved into fatty acids and monoglycerides, which due to the interaction with bile acids are quickly absorbed in the upper small intestine.
Protease helps break down proteins to free amino acids and polypeptides.
Coated tablets is not soluble in the acid environment of the stomach and prevents collapse under the influence of pancreatic enzyme of gastric juice.
Pancreatin - indications for use
The indication for a pancreatin replacement therapy for exocrine pancreatic insufficiency:
- chronic pancreatitis;
- Cystic fibrosis (cystic fibrosis);
- condition after irradiation.
Also according to the instructions Pancreatin is prescribed for:
- diarrhea of non-infectious origin, flatulence;
- chronic diseases of the biliary tract, biliary tract obstruction or pancreatic ducts;
- violation of digestion, including the following resection of the small intestine or stomach;
- preparation for X-ray and ultrasound of the abdominal cavity with the aim of decontamination of the intestine.
The indications for a violation of pancreatin chewing function, as well as excessive consumption of food or eating indigestible plant food by persons with normal function of the gastrointestinal tract.
Dosing and dosing regimen of pancreatin
According to the instructions Pancreatin for ingestion. Tablets drink during a meal or immediately after him, drinking plenty of fluids. The dosage depends on the age of the patient and indications for pancreatin.
Typically, instructions Pancreatin administered in a dosage of 1-4 tablets each meal. If necessary, the dose may be increased to 1, 5-2 times. The maximum daily dose for adults is 21 tablets. In case of total failure of exocrine pancreatic function, the dosage may be increased to 57 pills a day, which is the daily human need for lipase.
The maximum daily demand for lipase adult is 15-20 thousand Ph. Eur. U. (ME), lipase / kg body weight, which corresponds to 2-3 tablets / kg body weight.
In cystic fibrosis children under four years prescribed pancreatin instructions Dosage 1 tablet / 7 kg of body weight. Children older than four years, the dosage is 1 tablet / 14 kg body weight.
The duration of treatment varies from a few days to several months, depending on the indications for pancreatin. If necessary, fixed replacement therapy the duration of treatment may amount to several years.
Contraindications to the use of pancreatin
According to the instructions Pancreatin is contraindicated in the following cases:
- Children under two years of age;
- acute pancreatitis;
- bowel obstruction;
- exacerbation of chronic pancreatitis;
- hypersensitivity to the drug.
In the opinion of Pancreatin well tolerated by patients. Sometimes you may experience the following side effects:
- Digestive system: constipation or diarrhea, nausea, a feeling of discomfort in the epigastric region. In cystic fibrosis pancreatin reviews can cause small bowel obstruction, strictures in the ileocecal region and the ascending colon.
- Other side effects: perianal irritation, malabsorption of folate, allergic reactions (with lactose intolerance and hypersensitivity to the drug).
In the opinion of Pancreatin long-term use can cause giperrukozuriyu, and the application of excessive doses - hyperuricemia.
Overdose pancreatin reviews causes the following symptoms: hyperuricemia, hyperuricosuria. Drug overdose in children can cause constipation. In these cases, the use of pancreatin should be discontinued and a symptomatic treatment.
The use of pancreatin during pregnancy and lactation
Safety drug during pregnancy not fully understood, however in this period pancreatin instructions designate only a hazard ratio of mother and fetus.
In the opinion of pancreatin may be used during lactation.
Appointment pancreatin according to the instructions in conjunction with the preparations of iron and folate reduce their absorption. The simultaneous use of pancreatin with antacids, alcohol-containing agents, tannin reduces the effect of the drug.
Storage conditions and shelf life of pancreatin
Store in a cool, dry place at a temperature not exceeding 15 degrees. Shelf life - 24 months.