Orungamin

 Orungamin - preparation rendering antifungal activity
 Orungamin - antifungal synthetic broad spectrum of action.

Pharmacological action

The active substance Orungamina has antifungal activity due to its ability to inhibit the synthesis of ergosterol cell membranes of fungi.

According to the instructions Orungamin exhibits activity against dermatophytes, yeasts and yeast-like fungi:

  • Microsporum spp .;
  • Cryptococcus neoformans;
  • Candida spp., Including Candida glabrata, Candida albicans and Candida krusei;
  • Histoplasma spp .;
  • Sporothrix schenckii;
  • Cladosporium spp .;
  • Blastomyces dermatitidis;
  • Fonsecaea spp .;
  • Aspergillus spp .;
  • Epidermophyton floccosum;
  • Trichophyton spp .;
  • Pityrosporum spp .;
  • Paracoccidioides brasiliensis.

Product form

Orungamin release dosage form in capsules with pink and blue transparent body lid containing 100 mg of active ingredient itraconazole as a light yellow microgranules. In 5 or 15 pieces per pack.

Also produces a number of unique Orungamina - capsule Itrazol, Irunine, itraconazole, Mikonihol, Rumikoz, Teknazol, Kanditral, Orun, Orungal, itraconazole oral solution Orungal and vaginal tablets Irunine.

Indications Orungamina

The preparation and analogues Orungamina used to treat:

  • Ringworm;
  • Tinea versicolor;
  • Kandidomikoz with mucous membranes or skin, including vulvovaginal candidiasis;
  • Fungal keratitis;
  • Deep visceral candidiasis;
  • Onychomycosis, which cause Musty mushrooms, dermatophytes, or yeast.

Furthermore, according to the instructions Orungamin prescribed for the treatment of systemic fungal infections:

  • Systemic aspergillosis and candidiasis;
  • Histoplasmosis;
  • Paracoccidioidomycosis;
  • Cryptococcosis including cryptococcal meningitis;
  • Blastomycosis;
  • Sporotrichosis;
  • Other tropical or systemic fungal infections.

Contraindications

According to the instructions Orungamin contraindicated to take:

  • In chronic heart failure;
  • At the age of three;
  • If you are hypersensitive to itraconazole;
  • Along with dofetilide, sertinolom, astemizole, levacetylmethadol, bepridilom, terfenadine, mizolastine, lovastatin, cisapride, pimozide, quinidine, simvastatin;
  • Simultaneously with preparations containing nisoliptin, ergot alkaloids, Eletriptan;
  • When fructose intolerance, glucose-galactose malabsorption and deficiency sucrase.

During pregnancy and lactation Orungamin approved for use with caution under strict indications.

Dosing Orungamina

 Orungamin capsules
 In order to achieve optimal therapeutic effect capsule Orungamina recommended to take immediately after a meal.

The dose of the drug and duration of treatment depends on the fungal infection:

  • When vulvovaginal candidiasis drug can be taken on two schemes: 2 capsules twice a day for one day or one capsule Orungamina once daily for 3 days. Also, for the local treatment of vulvovaginal candidiasis, including recurrent, can be used analogue Orungamina - Irunine in the form of vaginal tablets;
  • When pityriasis versicolor usually treatment is carried out for a week, taking 2 capsules once;
  • When ringworm smooth skin Orungamin can be used for the treatment of tinea versicolor scheme or to take 15 days one capsule;
  • Fungal keratitis is usually treated over a long period and is three weeks, to 2 capsules per day;
  • In oral candidiasis Orungamin Review is effective when taking one capsule a day for 15 days;
  • When onychomycosis Orungamin instructions for taking over the three months to 1 capsule a day or two capsules twice a day for a week, and then repeat the course after a break of 3 weeks. As a rule, for the treatment of onychomycosis of feet need three courses of treatment, brush - just two;
  • The duration of treatment of systemic fungal infections varies from two to twelve months, depending on the pathogen. Recommended dosage - 1-2 capsules Orungamina 1-2 times a day.

When violations of immunity, such as neutropenia or AIDS, to take a dose of the drug or analogue Orungamina should redouble. In renal and liver failure may also need to increase the dose.

Orungamin of instructions should be taken with caution at the same time:

  • Calcium channel blockers - dihydropyridine and verapamil;
  • HIV protease inhibitors - indinavir, ritonavir, saquinavir;
  • Some anticancer drugs - docetaxel, vinca alkaloids, trimetrexate, busulfan;
  • Oral anticoagulants;
  • Some immunosuppressants - tacrolimus, cyclosporine, sirolimus;
  • Other drugs - reboxetine, digoxin, ebastine, carbamazepine, methylprednisolone, buspirone, rifabutin, alfentanil, brotizolamom, alprazolam.

In the application of proton pump inhibitors or H2 histamine receptors should be taken with the capsule Orungamina acidic drinks.

If you receive more than one month Orungamina recommended to monitor liver function.

Side effects Orungamina

When applying for Orungamina reviews side effects are very rare. Most often they appear as a violation of taste perception, headache, abdominal pain, vomiting, rash and diarrhea. Several less Orungamin Review can cause:

  • Neutropenia, leukopenia, thrombocytopenia;
  • Angioedema, hypersensitivity;
  • Pollakiuria, urinary incontinence, menstrual disorders, erectile dysfunction;
  • Edema;
  • Peripheral neuropathy, paresthesia, dizziness, hypoesthesia;
  • Toxic epidermal necrolysis, pruritus, Stevens-Johnson syndrome, erythema multiforme, leykoklastichesky vasculitis, exfoliative dermatitis, urticaria, photosensitivity, alopecia;
  • Myalgia, arthralgia;
  • Hyperbilirubinemia, dyspepsia, acute liver failure, constipation, hepatitis, hepatotoxicity;
  • Impaired vision, including blurring and diplopia, as well as transient or permanent deafness, tinnitus;
  • Hypokalemia, hypertriglyceridemia;
  • Serum sickness, anaphylactic and anaphylactoid reactions;
  • pulmonary edema.

In cases of neuropathy and heart failure are advised to stop taking the drug.

storage conditions

Orungamin relates to antifungal drugs List B with a shelf life of 36 months and prescription.





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