Ornisid - pharmacological agents with antibacterial and antiprotozoal properties.
Structure and Composition
Ornisid available in tablets for oral administration in the form of suppositories for vaginal administration. The active ingredient - ornidazole. Ornisida Tablets contain 250 mg or 500 mg (Ornisid forte) active ingredient. Vaginal suppositories containing 500 mg Ornisid ornidazole.
Besides the active substance in the tablets include Ornisid auxiliaries: microcrystalline cellulose, potato starch, magnesium stearate, gidroksimetiletiltsellyuloza. Auxiliary components vaginal suppositories include lactose, dihydrogenphosphate, anhydrous citric acid, magnesium stearate, PVP-gelatinized starch, corn starch.
Ornisid Tablets (250 mg) are available in blister pack of 20 pieces in carton one blister. Tablets Ornisid forte (500 mg) are available in blister pack of 10 tablets, in a cardboard blister pack 1. Vaginal Ornisid candles are available in blister of 3 pieces.
Pharmacological action Orinisida
According to the instructions Ornisid antibacterial and antiprotozoal properties. Ornizadol is a derivative of 5-nitroimidazole, it inhibits bacterial DNA synthesis and thus leads to the death of microorganisms.
Ornisid active against Trichomonas vaginalis, amoeba dysentery, giardia, gardenerelly, as well as in respect of certain anaerobic bacteria (Bacteroides, some clostridia, fuzobakterii, anaerobic cocci). Aerobic microorganisms are not sensitive to this drug.
After ingestion Ornisid instructions for rapidly absorbed, high bioavailability (90%), the maximum blood concentration after oral observed after 1-2 hours.
According to the instructions Ornisid excreted mainly by the kidneys (70%) and bowel (25%). The drug crosses the blood-brain barrier, the placenta and breast milk.
Ornisid Tablets are recommended for the treatment of trichomoniasis, amebiasis, giardiasis, amoebic dysentery, extra-intestinal amebiasis, as well as for the treatment of infections caused by anaerobes. Tablets Ornisida can be used for preventing postoperative anaerobic infections bowel and gynecological surgery.
Suppositories Ornisid recommended for the treatment of urogenital trichomoniasis and nonspecific vaginitis of various origins.
Tablets Ornisid contraindicated in case of hypersensitivity to the ingredients of the drug, liver failure phenomena, organic diseases of the nervous system, as well as in the first 12 weeks of pregnancy (I trimester) and during lactation.
Ornisid vaginal suppositories are contraindicated in hypersensitivity to the ingredients of the drug, as well as leukopenia, organic diseases of the nervous system (including epilepsy), during the first trimester of pregnancy and lactation.
According to the instructions Ornisid should be used with caution in the second and third trimesters of pregnancy and in patients with a history of leukopenia.
Use during pregnancy and lactation
Ornisid contraindicated in the first trimester of pregnancy. Suppositories Ornisid can be used with caution in the second and third trimester of pregnancy only under medical supervision. If a woman breast-feeding, you should take the drug, then the treatment Ornisidom breastfeeding should be discontinued.
Dosing and Administration Ornisida
Ornisid Tablets (250 mg) with trichomoniasis are assigned 2 times daily 500 mg, the treatment of this disease is 5 days. Children dosage of the drug is calculated based on the weight of the child (25 mg / kg / day).
Under anaerobic infections Ornisid recommended to apply 500 mg 2 times a day.
In amoebic dysentery This drug is given at 1, 5-2 g once a day. Babies dosage calculated based on the formula of 40 mg / kg / day. Duration of treatment - 3 days.
In the treatment of giardiasis Ornisid assigned to 1, 5 g per day, children the dose is calculated as 40 mg / kg / day. The course of treatment is 1-2 days.
For the prevention of anaerobic infections recommended single dose Ornisida dose of 500-1000 mg prior to surgery and after surgery, 500 mg 2 times a day for 3-5 days.
Suppositories Ornisid be inserted deep into the vagina after preliminary hygienic treatment of the external genitalia.
If trichomoniasis is assigned 1 Ornisida candle at night. Typically intravaginal combined with oral tablets of the drug (1, 5 g once or 1g essentially for 5 days).
According to the instructions Ornisid in rare cases can cause dizziness, tremors, discoordination movements, convulsions, peripheral neuropathy, nausea, vomiting, diarrhea.
In case of overdose with this drug may cause seizures (epileptic-like), depression, peripheral neuritis. Treatment is symptomatic, with seizures shows diazepam.
Interaction with other drugs
When using Ornisida should be aware that the drug enhances the effect of anticoagulants and prolong the effects of muscle relaxant vecuronium bromide.
According to the instructions Ornisid compatible with alcohol.
Special instructions for use Ornisida
In the treatment of urogenital trichomoniasis should immediately treat both partners to avoid reinfection.