Octagam

 The solution Octagam
 Octagam - immunological drug used for substitution, and therapies.

Pharmacological action

Immunoglobulin G, included in the Oktagama exert immunomodulatory effects. According to the instructions Octagam reduces the risk of infections in primary and secondary immunodeficiency, with the antibodies have all the properties that are characteristic of a healthy person.

Product form

Octagam discharged as a clear, light yellow solution for infusion in 1 ml containing 50 mg and 100 mg (10% Octagam) plasma protein. The glass vials 20, 50, 100 and 200 ml.

Indications Oktagama

Octagam is used as replacement therapy in:

  • Primary immunodeficiency syndrome, including congenital agammaglobulinemia and hypogammaglobulinemia, severe combined immunodeficiency, ungraded variable immunodeficiency, Wiskott-Aldrich syndrome;
  • Recurrent infections in children c congenital HIV infection;
  • Myeloma or chronic lymphocytic leukemia with recurrent infections and severe secondary hypogammaglobulinemia.

As therapies Octagam under the instruction prescribed for:

  • Idiopathic thrombocytopenic purpura with high risk of bleeding in adults and children or in front of operations;
  • Kawasaki disease;
  • Guillain-Barre syndrome;
  • Bone Marrow Transplant.

Contraindications

According to the instructions to use Octagam contraindicated in case of hypersensitivity or intolerance to homologous immunoglobulins, as well as in the presence of antibodies to IgA.

Octagam during pregnancy has no adverse effects on the fetus, as evidenced by clinical experience. Contained in the preparation antibodies are excreted in breast milk and may have a protective effect in the child. However, the safety of Oktagama during pregnancy and lactation has not been studied, so appointed in this period with caution.

Dosing Oktagama

 The solution for infusion Octagam
 The duration of therapy and dose Oktagama according to the instructions determined individually.

As a general rule, the duration of substitution therapy in primary immunodeficiencies is three to six months. Octagam is administered with an interval of 2-4 weeks, and the dose can vary from 200 to 800 mg per 1 kg. The maximum dose is usually administered in the early treatment of acute infections.

With multiple myeloma or chronic lymphocytic leukemia with recurrent infections and severe secondary hypogammaglobulinemia Octagam is administered once a month by 200-400 mg per 1 kg. At the same dose of the drug used in children with recurrent infections, congenital HIV infection.

When idiopathic thrombocytopenic purpura on the first day of treatment for acute episodes administered higher doses Oktagama - 0, 8-1 g / kg. Re-introduction of the drug can be made on the third day of treatment.

When Guillain-Barre usually carried therapy to 7 days at 400 mg / kg per day.

In the treatment of Kawasaki disease is administered once to 2 g / kg. If necessary, this dose can be divided into equal portions and administered over five days. In the opinion of Octagam is most effective when applied simultaneously with acetylsalicylic acid.

When administered intravenously Oktagama instructions on the initial velocity should not exceed 15 drops per minute. If the drug does not cause undesirable side reactions, the introduction rate can be increased to a maximum - 54 drops per minute.

Oktagama solution prior to administration is recommended to bring the temperature of the body.

According to the instructions Octagam not be mixed in the same system with other drugs, as well as used for the introduction of the solution containing the precipitate.

Adjustments in dosage Oktagama pregnancy in cases where the drug during this period is not required.

In overdose Oktagamom may be an increase in blood viscosity and water retention in the body. Infants not use this drug in conjunction with calcium gluconate.

When pursued Oktagamom therapy should take into account that at high doses the immunoglobulin may result in increased plasma viscosity, thereby increasing the risk of thromboembolic complications and ischemia. It is also not recommended during treatment with diuretics to use acting on the renal tubules.

side effects

Octagam of reviews in most cases well tolerated, but may cause a variety of side effects:

  • Headache, chills, pyrexia;
  • Lowering blood pressure;
  • Fever;
  • Arthralgia, back pain and lower back;
  • Nausea or vomiting;
  • Hypercreatininemia.

Acute renal insufficiency of Octagam reviews often causes at the age of 65 years, as well as:

  • Kidney failure in history;
  • Hypovolemia;
  • Diabetes;
  • Concomitant therapy nephrotoxic drugs;
  • Obesity.

The most common allergic reactions when using Oktagama of reviews are itching and skin rash.

Very rarely Oktagama administration leads to the development of collapse, respiratory failure, anaphylactic shock, reversible aseptic meningitis, rash, pulmonary edema, thromboembolic complications, bronchospasm, pyrexia, malaise, pulmonary embolism, dyspnoea.

storage conditions

Octagam refers to a number of immunomodulatory drugs at the doctor's prescription. Shelf life of the solution in bottles of 50, 100 and 200 ml - 2 years in bottles of 20 ml - 1, 5 years.





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