Norepinephrine

 Norepinephrine
 Noradrenaline tartrate - a drug that lowers blood pressure.

Pharmacological action

Norepinephrine is a hormone produced by the adrenal glands, narrows the small blood vessels, increases heart rate and pulmonary ventilation, dilates the bronchi, decreases intestinal motility, it relaxes the muscles.

A synthetic analogue of the hormone noradrenaline acts as a drug norepinephrine, dilates blood vessels and bronchial lumen, increasing the pressure, stimulates contraction of the heart.

The active ingredient of the drug - norepinephrine.

Product form

Tartrate norepinephrine released into solution. Analogs of the drug - Levarterenol, Noreksadrin, Levarterenolabitartrat, Levofed, norepinephrine Norepinephrine

Indications noradrenaline

Norepinephrine according to the instructions prescribed for acute pressure drop caused by the surgery, poisoning, trauma.

The drug is also used to restore pressure on operations to remove a tumor of the adrenal glands.

Contraindications

Norepinephrine according to the instructions can not be administered in cases where the operations employed or ftorotanovy cyclopropane anesthesia.

Also, the drug is contraindicated in complete atrioventricular blockade, heart failure, atherosclerosis.

After administration of noradrenaline may disrupt heart rhythm, sharply narrowed lumen of the peripheral vessels, so if severe cardiogenic, hemorrhagic shock resuscitation considered this inefficient. You should also take into account the fact that under the influence of the drug increases the need of the heart muscle of oxygen.

A combination drug with quinidine, cardiac glycosides, tricyclic antidepressants, agents for inhalation general anesthesia (enflurane, isoflurane, chloroform, halothane, methoxyflurane) increases the risk of developing arrhythmia.

Drugs such as phentolamine, labetalol, doxazosin, phenoxybenzamine, terazosin, prazosin, talazozin, haloperidol, phenothiazines, loxapine, thioxanthen reduce vasodilator effect of the drug. The efficacy of the overall decrease diuretics and drugs lowering blood pressure.

Thyroid hormones in combination with the drug increases the risk of coronary insufficiency.

Dosing instructions for norepinephrine

 Levofed - analogue of noradrenaline
 Synthetic hormone norepinephrine infusion administered intravenously. Before introducing it should be diluted in glucose or isotonic sodium chloride solution so that one liter of solution had 2-4ml 0, 2% gidroartrita noradrenaline.

Begin to inject the drug at a rate 10-15kap minute. In order to raise the pressure to the level 100-115mm.rt. Article speed of injection was increased to 20-60kap minute.

side effects

With the introduction of the drug at high speed there tachycardia, headache, nausea, chills.

Intramuscularly or subcutaneously Norepinephrine not administered because tissue necrosis may occur. If this happens, the patient is administered diluted in saline 50-10ml phentolamine.





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