Nitrosorbid

 Nitrosorbid pills
 Nitrosorbid - for stimulating blood circulation.

Pharmacological action

Nitrosorbid expands peripheral vessels, mostly affecting the venous vessels, reducing myocardial oxygen, has koronarorasshiryayuschee effect, reduces the flow of blood to the right atrium and the pressure in the pulmonary blood flow in areas with reduced blood supply to redistribute coronary blood flow. In patients with ischemic drug improves exercise tolerance.

After receiving sublingual form Nitrosorbid its action develops in 2-5min after capsule or tablet - after 15-40min, prolonged forms - half an hour. The duration of action is 1-2h, respectively, 4-6ch and 12h.

After irrigation of the mucous in the mouth spray action Nitrosorbid developing for 30 seconds and lasts for 15 min or an hour.

Product form

Nitrosorbide release tablets, sublingual spray, capsules, sustained-concentrate solution for adhering the wafer on the gums.

Indications Nitrosorbid

Nitrosorbid according to the instructions indicated for the treatment and prevention of angina pectoris, the treatment of acute heart attack to recover after a heart attack, removal of spasm of the coronary and peripheral arteries, pulmonary edema, treatment of chronic congestive heart failure, hypertension.

Instructions for use Nitrosorbid

When using a spray injected dose Nitrosorbid 1-3 in the mouth with a break of 30 seconds, holding the breath. After five minutes, if you do not get better, a second irrigation. It should be kept under the control of blood pressure and heart rate.

For the prevention of coronary spasm are effective when administered catheter Nitrosorbid 1-2 doses which are administered before the procedure.

Tablets Nitrosorbid prescribed to take 2, 5-5mg every two or three hours, if necessary. To stop the attack stenokardicheskie tablet placed under the tongue to speed up the effect it can chew.

Inside Nitrosorbid take pills for 4-5r 10-20mg / day for 60min before meals or after meals 120min. Tablets do not chew, wash down with water. If a sufficient effect is not observed after treatment, with 3-5 days of treatment the dosage is increased to 60-120mg / day.

Tablets, which contain 5, 10, 20 mg of the active substance take 3-4r / day, 20 mg tablets retard (retard) receiving 2-3r / day, retard tablets 60 and 40mg - twice, sustained release tablets 120mg - one p / day.

 The solution was administered intravenous drip Nitrosorbid
 Nitrosorbid on effective instruction and in the treatment of chronic heart failure - he was appointed to take on 3-4r 10-20mg / day.

The solution is introduced dropwise intravenously Nitrosorbid - 0, 1mg / ml at a rate of 3-4 drops / min.

Films with nitrosorbid 20-40mg stick on the gum 1-3 p / day, alternating sides.

Side effects

After applying Nitrosorbid may occur: flushing of the facial skin, headache, decreased pressure, dizziness, tachycardia, nausea, collapse, dry mouth, vomiting, a slight burning sensation on the tongue, drowsiness, stiffness, deterioration of psychomotor reactions, blurred vision, rash skin.

In overdose Nitrosorbid can develop collapse, cause headache, blurred vision, palpitations, syncope, seizures, redness of the skin, dyspnea, vomiting, sweating, bradycardia, increased intracranial pressure, coma, anoxia, cyanosis, paralysis.

For treatment of overdose should wash out the stomach, with the development of methemoglobinemia - enter 1-2mg / kg methylthioninium chloride 1%. As a symptomatic treatment for reducing pressure injected phenylephrine. Introduction adrenaline ineffective.

Contraindications

You can not assign Nitrosorbid in case of hypersensitivity to the facility.

Intravenous administration of the drug is contraindicated in hemorrhagic stroke, with traumatic brain injury, cardiac tamponade, increased intracranial pressure, hypovolemia, constrictive pericarditis.

Also Nitrosorbid instructions indicated that the drug with caution in all its pharmaceutical forms should be prescribed for acute myocardial, traumatic brain injury, hemorrhagic stroke, glaucoma, hyperthyroidism, anemia, hypotension, hypertrophic cardiomyopathy, severe chronic renal failure, hepatic insufficiency, during lactation during pregnancy.

Contraindicated means children.

Tablets should not be taken at Nitrosorbid malabsorption syndrome, and increased gastrointestinal motility.





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