Nifedipine - means that lowers blood pressure.
Nifedipine has antiischemic action prevents flow of calcium into vascular smooth muscle cells and cardiomyocytes, reduces pressure, expanding the peripheral and coronary arteries, reduces the total peripheral vascular resistance, myocardial contractility (slightly) improves coronary blood supply.
Judging by the reviews, Nifedipine on the conductivity of the myocardium is not affected, antiarrhythmic activity is not.
Releasing Nifedipine tablets of conventional and long-acting solution.
Nifedipine is used according to indications: coronary heart disease with stenokardicheskie attack, hypertension, including kidney.
Nifedipine is combined with verapamil can be used in nephrogenic hypertension - drugs slow the progression of kidney failure.
Also, the drug included in the complex therapy of chronic cardiac insufficiency.
In combination with bronchodilators Nifedipine preparations can be applied according to the instructions in bronchial asthma for maintenance treatment.
Good reviews of nifedipine, used for Raynaud's disease - means a positive effect on cerebral hemodynamics.
The tablets are taken orally at 0, 01-0, 3-4r 01gr / day (up to 120mg / day). Treatment lasts 1-2mes and more.
Nifedipine indication of hypertensive crisis or attack stenokardicheskie take sublingually, one 10 mg tablet placed under the tongue, resolving a few minutes. To speed up the onset of the therapeutic effect, the pill can get to the core, but do not swallow, leave under the tongue to dissolve. Thus the patient for half an hour should be in a supine position. After 20-30min receiving means is repeated, increasing the dosage of sometimes up to 20-30mg. After the attack stopped, the patient is transferred to the reception means inside.
Nifedipine sustained-release tablets effectively for long-term treatment. Assign them to take 1-2r / day for 20 mg, sometimes two p / day for 40 mg. Tablets are taken after a meal, do not chew.
Intravenous to remove a person from a hypertensive crisis means it is recommended to enter in the amount of 0, 005gr for 4-8ch, which corresponds to 6, 3-12, 5 ml of infusion solution per hour.
Permissible dosage instructions on the Nifedipine - 15-30mg / day.
Nifedipine can cause such side effects are: flushing of the skin, tachycardia, hypotension, peripheral edema, bradycardia, asystole, increased stenokardicheskie attack, nausea, diarrhea, heartburn, impairment of liver function, gingival hyperplasia, dyspepsia, headache, paresthesia, muscle pain, blurred vision and sleep, leukopenia, thrombocytopenia, increase daily urine output, gynecomastia, skin rash, impaired kidney function (with prolonged use of drugs or in high doses).
There are reviews of nifedipine, causing a burning sensation when administered intravenously at the injection site.
The instructions Nifedipine also stated that the intracoronary administration for one minute after the start of infusion may be hypotension, increased heart rate. These symptoms disappear gradually over 5-15min.
You can not use in patients with hypotension, collapse, severe heart failure, cardiogenic shock, severe aortic stenosis, hypersensitivity.
During lactation, pregnancy Nifedipine is not recommended, because in the course of his studies found teratogenic and embryotoxic action. But in gynecological practice sometimes prescribe nifedipine during pregnancy to reduce the pressure when other means (for example, motherwort or dopegit) does not help. It is also noted that nifedipine during pregnancy helps reduce the tone of the uterus, although widespread in this indication has not yet received nifedipine.