Naksodzhin - pharmacological agents from the group of synthetic antibacterial drugs used to treat infections caused by protozoa (Trichomonas, amoeba, lyabmlii et al.).
Structure and Composition
According to the instructions Naksodzhin contains the active substance - nimozoral and auxiliary components (microcrystalline cellulose, corn starch, methyl cellulose, stearic acid).
This drug is in the form of tablets (round, white, with a break line on one side).
Tablets Naksodzhin Available in bottles of dark glass, 1 vial of 6 tablets of the drug.
Pharmacological action Naksodzhin
This drug has antiprotozoal action (ie, has activity against protozoa, which include Giardia, Trichomonas, amoebae, Toxoplasma, and others.). Naksodzhin mainly active against Trichomonas vaginalis and other protozoa (Entamoeba histolytica, Giardia interstinalis), as well as against Gardenerella vaginalis and Bacteroides.
According to the instructions Naksodzhin is well absorbed after oral administration. Withdrawal of the drug is mainly through the kidneys. The concentration of the drug and its metabolites in urine and vaginal secretions considerably higher protivotrihomonadnyh necessary dosages.
Naksodzhin indicated for use in infections caused by Trichomonas vaginal (Trichomonas vaginalis), when vaginitis caused gardenerelloy (Gardenerella vaginalis), as well as giardiasis, amoebiasis, Vincent gingivitis (acute necrotizing ulcerative gingivitis).
Hypersensitivity to the ingredients of the drug, severe blood disease, severe renal and hepatic failure.
With caution should be used when Naksodzhin neurological diseases in the acute period.
It is not recommended to drink alcohol during treatment with this drug (for at least 48 hours after the Naksodzhin).
Use during pregnancy and lactation
According to the instructions Naksodzhin not recommended for use during pregnancy and lactation, since it is possible the demonstration of mutagenic properties of the drug.
Instructions Naksodzhin: Dosage and administration
This drug is taken by mouth after eating. There are several schemes for the application Naksodzhin depending on the disease and the patient's age.
In the treatment of trichomoniasis adults recommend the following scheme:
- 2 g Naksodzhin after eating only once;
- then 1 g of the drug every 12 hours (3 times);
- followed by 0 25 g Naksodzhin 3 times a day for 5-7 days.
In the treatment of trichomoniasis in children should receive Naksodzhin 15 mg / kg / day (the entire dose to 3 divided doses) for 5-7 days.
In the treatment of adult amebiasis appointed Naksodzhin 500 mg twice daily for 5-10 days. Babies for the treatment of this disease recommended 20 mg / kg / day (dose divided into 2 doses) for 5-10 days.
In the treatment of giardiasis adults should take 500 mg Naksodzhin 2 times a day for 5-7 days. Children dose is calculated based on the formula of 15 mg / kg / day (divided into 2 doses), Naksodzhin in this case should be used for 5-7 days.
When treating gardenerelleza adults appoint 500 mg 2 times a day for a week, or 2 g once Naksodzhin.
In the treatment of adult gingivitis Vincent Naksodzhin drug should be taken within 2 days of 500 mg 2 times a day.
In the opinion of Naksodzhin well tolerated by patients of all ages. Experience side effects are rare and poorly expressed and, as a rule, do not require discontinuation of the drug.
Possible side effects: nausea, heartburn, vomiting, skin rash, drowsiness, dizziness, metallic taste in the mouth, dry and coated tongue, stomatitis.
In the opinion of Naksodzhin be taken after a meal that gets rid of dyspeptic adverse reactions. Rarely, this medication can cause leukopenia, discomfort in the urethra, and dark urine.
Symptoms of overdose of this drug: dyspepsia (nausea, vomiting, diarrhea), dizziness and also possible appearance of neurological symptoms (tingling, paresthesia, convulsions, stupor). Treatment of overdose is reduced to gastric lavage and symptomatic therapy appointment.
The purpose of this drug to patients with neurological diseases is possible only under careful medical supervision.
In the treatment of trichomoniasis Naksodzhin therapy should be carried out once the two partners to avoid reinfection (even when the second of these symptoms are absent).
Interaction Naksodzhin with other drugs
The consumption of alcohol while taking this drug may cause disulfiramopodobnyh reactions, which is the appearance of nausea, facial flushing, palpitations, low blood pressure, vomiting, intense fear of death.
It should also be borne in mind that according to the instructions Naksodzhin enhances anticoagulant effect of warfarin.
Simultaneous treatment with phenobarbital may reduce Naksodzhin content in blood serum.
Effects on ability to drive vehicles and other mechanisms
There is no information on the impact of Naksodzhin on ability to drive and to work with complex mechanisms.
An analogue of a drug Naksodzhin nimorazol.
There are also drugs with a similar action (eg, metronidazole, tinidazole, Clione, Trichopolum, Osarbon, flags).
Consult with your doctor if you want to replace analogue Naksodzhin.